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| 树突状细胞在大鼠穿透性角膜移植排斥反应中的作用 | |
| 引用本文： | 白浪,陆晓和,党森涛,周瑾. 树突状细胞在大鼠穿透性角膜移植排斥反应中的作用[J]. 南方医科大学学报, 2007, 27(1): 72-74 |
| 作者姓名： | 白浪 陆晓和 党森涛 周瑾 |
| 作者单位： | 南方医科大学珠江医院眼科,广东,广州,510282;南方医科大学珠江医院眼科,广东,广州,510282;南方医科大学珠江医院眼科,广东,广州,510282;南方医科大学珠江医院眼科,广东,广州,510282 |
| 摘 要： | 目的 观察大鼠角膜组织中树突状细胞的分布,以了解树突状细胞在穿透性角膜移植排斥反应中的作用.方法 制作大鼠穿透性角膜移植模型,观察角膜透明度、新生血管.采用免疫组织化学方法检测OX-62 树突状细胞在角膜的分布.结果 术后角膜植片均出现不同程度的新生血管、角膜水肿、混浊、基质增厚.排斥反应发生率100%.正常角膜组织中未见OX-62 树突状细胞分布,在发生急性排斥反应的角膜上皮层中有阳性细胞表达.脾脏阳性细胞表达与文献报道一致.结论 OX-62 树突状细胞出现在移植后发生排斥的角膜组织中,角膜组织中的树突状细胞可能参与角膜移植后的免疫反应. |
| 关 键 词： | 树突状细胞 OX-62 角膜 移植排斥反应 免疫组织化学 |
| 文章编号： | 1673-4254（2007）01-0072-03 |
| 收稿时间： | 2006-04-24 |
| 修稿时间： | 2006-04-24 |
Role of dendritic cells in graft rejection after penetrating keratoplasty |
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| BAI Lang,LU Xiao-he,DANG Sen-tao,ZHOU Jin. Role of dendritic cells in graft rejection after penetrating keratoplasty[J]. Journal of Southern Medical University, 2007, 27(1): 72-74 | |
| Authors: | BAI Lang LU Xiao-he DANG Sen-tao ZHOU Jin |
| Affiliation: | Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. bailangsfy@163.com |
| Abstract: | Objective To gain insight into the role of dendritic cells in graft rejection following penetrating keratoplasty by investigating their distribution in rat cornea. Methods Orthotopical corneal transplantation was performed and immuno- histochemical staining of the whole-mount cornea and the spleen tissue specimen employed to determine the distribution of the dendritic cells in the cornea. Results Graft rejection occurred in all rats following the transplantation. No OX-62 dendritic cells were found in normal cornea but they were present in the epithelium of the cornea graft with allograft rejection. Conclusion OX-62 dendritic cells presenting in the rejected cornea may be related to acute graft rejection after penetrating keratoplasty. |
| Keywords: | dendritic cells OX-62 cornea allograft rejection immunohistochemistry |
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