Overcoming inhibition in the spindle checkpoint |
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| Authors: | Vincent Vanoosthuyse Kevin G. Hardwick |
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| Affiliation: | Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom |
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| Abstract: | Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887–2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing. |
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| Keywords: | Kinetochore, Ipl1/Aurora B protein kinase, PP1/Glc7 protein phosphatase I, Fin1, 14– 3– 3, SILAC quantitative mass spectrometry |
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