| 同步加量放疗技术在非小细胞肺癌脑转移患者中的应用 |
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| 引用本文： | 王浩,吴磊,王天昶,李涛,王亚丽,高艳梅,刘秋芳. 同步加量放疗技术在非小细胞肺癌脑转移患者中的应用[J]. 现代肿瘤医学, 2014, 0(9): 2075-2078. DOI: 10.3969/j.issn.1672-4992.2014.09.22 |
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| 作者姓名： | 王浩 吴磊 王天昶 李涛 王亚丽 高艳梅 刘秋芳 |
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| 作者单位： | 陕西省肿瘤医院,陕西 西安 710061 |
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| 基金项目： | 陕西省科技厅科技自然项目基金 |
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| 摘 要： | 目的:评估同步加量放疗技术在非小细胞肺癌（non-small cell lung cancer，NSCLC）脑转移应用中的临床疗效、不良反应、生存时间，探索该技术的可行性。方法:76例NSCLC脑转移患者以不同分割模式分为A组（42例）和B组（34例）。A组患者全脑放疗DT 40Gy/（20f·4周）后局部推量DT 20Gy/（10f·2周），B组患者全脑放疗DT 36Gy/（20f·4周）全程同步加量适形放疗DT 24Gy/（20f·4周）。比较两组放疗疗效、不良反应、半年、1年总生存率。结果:采用 RECIST 1.1标准，A组放疗有效率为95.2%(40/42)，B组有效率为97.1%（33/34），两组疗效未见统计学差异。A、B两组患者在血液毒性、神经系统受损、消化道反应、脱发等方面均未见明显异常。A组中位生存时间为8.94个月，患者半年、1年生存率为71.4%、35.7%；B组患者中位生存时间为9.47个月，半年、1年生存率为82.4%、38.2%，两组无统计学差异。结论:两种分割模式在临床疗效、不良反应、生存时间方面疗效相当。全脑照射全程同步加量治疗脑转移近期疗效确切，患者耐受性很好，可缩短放疗时间。
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| 关 键 词： | 脑转移 放射治疗 同步加量 疗效分析 |
Simultaneous integrated boost conformal radiotherapy in non -small cell lung cancer patients with brain metastases |
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| Wang Hao,Wu Lei,Wang Tianchang,Li Tao,Wang Yali,Gao Yanmei,Liu Qiufang. Simultaneous integrated boost conformal radiotherapy in non -small cell lung cancer patients with brain metastases[J]. Journal of Modern Oncology, 2014, 0(9): 2075-2078. DOI: 10.3969/j.issn.1672-4992.2014.09.22 |
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| Authors: | Wang Hao Wu Lei Wang Tianchang Li Tao Wang Yali Gao Yanmei Liu Qiufang |
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| Affiliation: | Shaanxi Province Tumor Hospital,Shaanxi Xi'an 710061,China. |
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| Abstract: | Objective:To observe the local control rate,survival rate and side effects of the patients with brain metastases by whole brain radiotherapy (WBRT) with local simultaneous integrated boost conformal radiotherapy (SIB-CR).Methods:Seventy-six patients with brain metastasis of NSCLC were randomly divided into group A (n=42) and group B (n= 34).Group A received 40Gy whole brain radiation in 20 fractions over four weeks followed by 20Gy focal radiation in 10 fractions over two weeks.Group B received 36Gy whole brain radiation in 20 fractions over four weeks with simultaneous integrated boost by 24Gy focal radiation in 20 fractions.Therapeutic effect,adverse reactions and survival time were evaluated.Results:Using RECIST 1.1 treatment response evaluation criteria，the clinical symptom remission rate was 95.2%(40/42) in group A，97.1%（33/34） in group B.There was no significantly difference between group A and group B.There was no significantly difference in hematological toxicity,gastrointestional reaction,nervous system damage and alopecia in two groups.The median survival time,six months and 1-year survival rates of the patients in group A were 8.94 months,71.4% and 35.7%,respectively showing no significant differences to group B were 9.47 months，82.4% and 38.2%,respectively.There was no significantly difference between group A and group B in remission rate，toxic reaction and survival time.Conclusion:Whole brain irradiation with simultaneous integrated boost conformal radiotherapy technique is effective in patients with brain metastases with shorter the total radiotherapy duration and can be well tolerated. |
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| Keywords: | brain metastases radiation therapy simultaneous integrated boost therapeutic effect |
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