|
|||||
|
|
Successful treatment of cytomegalovirus enteritis after unrelated allogeneic stem cell transplantation by the infusion of ex vivo‐expanded CD4+ lymphocytes derived from the recipient's peripheral blood donor cells |
|
| Authors: | T. Muto Y. Takeda S. Tsukamoto S. Sakai N. Mimura C. Ohwada M. Takeuchi E. Sakaida S. Ota T. Iseki N. Shimizu T. Morio C. Nakaseko |
| Affiliation: | 1. Department of Hematology, Chiba University Hospital, Chiba, Japan;2. Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan;3. Department of Pathology, Chiba University Hospital, Chiba, Japan;4. Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan;5. Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan |
| Abstract: | Adoptive immunotherapies have been developed for antiviral agent‐refractory cytomegalovirus (CMV) disease after stem cell transplantation (SCT). However, the application of such strategies is limited, particularly in terms of need for donor cooperation regarding blood sampling and inaccessibility in the setting of cord blood transplantation. Herein, we describe the first successful treatment of antiviral agent‐refractory CMV enteritis after allogeneic SCT by the infusion of ex vivo‐expanded donor‐derived CD4+ lymphocytes obtained from the recipient's peripheral blood. |
| Keywords: | cytomegalovirus enteritis donor lymphocyte infusion allogeneic stem cell transplantation CD4+ lymphocyte |