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| 孕妇IgG抗A（抗B）的效价积分对新生儿溶血病贫血严重程度的预判价值 | |
| 引用本文： | 汤伟娴,金沙,郑皆炜,叶珍,刘曦,沈伟. 孕妇IgG抗A（抗B）的效价积分对新生儿溶血病贫血严重程度的预判价值[J]. 诊断学理论与实践, 2018, 17(4): 449-452. DOI: 10.16150/j.1671-2870.2018.04.018 |
| 作者姓名： | 汤伟娴 金沙 郑皆炜 叶珍 刘曦 沈伟 |
| 作者单位： | 1.上海市第一妇婴保健院,上海 200040; 2.上海市血液中心,上海 200051 |
| 摘 要： | 目的：探讨采用母亲体内IgG抗A（抗B）的效价积分对新生儿溶血病严重程度进行预判的价值。方法：检测27例新生儿溶血病患儿的红细胞计数、血红蛋白、红细胞比容和其母亲的IgG抗A（抗B）效价、效价积分,对其进行趋势线计算和相关性分析。结果：母亲的IgG抗A（抗B）效价积分和效价上升时,患儿的红细胞计数、血红蛋白含量、红细胞比容都下降;而在母亲抗体效价相同的情况下,效价积分越高,患儿的红细胞计数、血红蛋白含量、红细胞比容越低。相关性分析显示,在对新生儿溶血病患儿的贫血程度的预判中,效价积分与患儿血红蛋白含量间的相关系数为-0.966,其母亲的IgG抗A（抗B）效价积分与患儿贫血程度间的相关性比抗体效价更密切。结论：孕妇IgG抗A（抗B）的效价积分在预判患儿贫血的严重程度中具有一定临床价值。 |
| 关 键 词： | 效价 效价积分 新生儿溶血病 |
| 收稿时间： | 2018-03-19 |
The predictive value of IgG anti-A/B titer score on severity of hemolytic disease of newborn |
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| TANG Weixian,JIN Sha,ZHENG Jiewei,YE Zhen,LIU Xi,SHEN Wei. The predictive value of IgG anti-A/B titer score on severity of hemolytic disease of newborn[J]. Journal of Diagnostics Concepts & Practice, 2018, 17(4): 449-452. DOI: 10.16150/j.1671-2870.2018.04.018 | |
| Authors: | TANG Weixian JIN Sha ZHENG Jiewei YE Zhen LIU Xi SHEN Wei |
| Affiliation: | 1. Shanghai First Maternity and Infant Hospital, Shanghai 200040, China; 2 Shanghai Blood Center, Shanghai 200051, China |
| Abstract: | Objective: To study the correlation of IgG anti-A/B titer score and the severity of hemolytic disease of newborn. Methods: The red blood cell count, hemoglobin and hematocrit value of 27 newborn with hemolytic disease and the IgG anti-A/B titer and titer score of their mother were measured and their correlations were analyzed. Results: With the increase in IgG anti-A/B titer and titer score of mother, the red blood cell count, hemoglobin and hematocrit values of newborn with hemolytic disease decreased. At the same IgG anti-A/B titer, the higher the titer score, the lower the red blood count, hemoglobin and hematocrit value were. Conclusions: According to the correlation analysis, the titer score is more closely related to the severity of hemolytic disease of newborn. For hemoglobin, the correlation coefficient was -0.966. The IgG anti-A/B titer score was of more clinical significance in predicting the severity of hemolytic disease in newborn. |
| Keywords: | Titer Titer score Hemolytic disease of newborn |
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