| E-cadherin的表达与肝细胞癌侵袭和转移的关系 |
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| 引用本文： | 洪坚善,彭浩,段小娴. E-cadherin的表达与肝细胞癌侵袭和转移的关系[J]. 基础医学与临床, 2005, 25(12): 1139-1142 |
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| 作者姓名： | 洪坚善 彭浩 段小娴 |
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| 作者单位： | 广西医科大学,肿瘤医院,胃肠乳腺外科,广西,南宁,530001;广西医科大学,肿瘤医院,病理研究室,广西,南宁,530001 |
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| 基金项目： | 广西青年科技基金（0229029） |
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| 摘 要： | 目的研究上皮性钙黏蛋白（E-cadherin）在人肝细胞癌（HCC）中的表达情况，探讨其与肝癌的相关性。方法选择56例有完整随访资料的肝细胞癌及相应癌旁组织标本、20例正常肝组织标本，用RT-PCR方法检测E-cadherinmRNA的表达；用免疫组织化学方法检测E-cadherin的表达。结果①E-cadherin在肝细胞癌组织中的表达显著低于癌旁组织和正常组织（P〈0．05），而在癌旁组织和正常组织中的表达无差异；②E-cadherin在肝癌组织中的表达与术后复发时间呈正相关（P〈0．05），与病理分期呈负相关（P〈0．05）；③癌组织中E-cadherin表达与肝外转移呈负相关（P〈0．05）；④癌旁组织中E-cadherin表达与术后复发时间呈正相关（P〈0．05）。结论E-cadherin表达缺失或下调与肝癌的分化程度、侵袭转移能力和复发倾向相关，对肝癌临床转归的评估有一定指导意义。
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| 关 键 词： | 上皮性钙黏蛋白 肝细胞癌 侵袭转移 |
| 文章编号： | 1001-6325(2005)12-1139-04 |
| 收稿时间： | 2005-07-07 |
| 修稿时间： | 2005-09-27 |
Relationship between expression of E-cadherin and invasion and metastasis of hepatocellular carcinoma |
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| HONG Jian-shan,PENG Hao,DUAN Xiao-xian. Relationship between expression of E-cadherin and invasion and metastasis of hepatocellular carcinoma[J]. Basic Medical Sciences and Clinics, 2005, 25(12): 1139-1142 |
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| Authors: | HONG Jian-shan PENG Hao DUAN Xiao-xian |
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| Affiliation: | Dept. Breast - Gastrointestinal Surgery, Cancer Hospital, Guangxi Medical University, Nanning 530001, China |
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| Abstract: | Objective To investigate expression of Ecadherin in hepatocellular carcinoma(HCC) and discuss their pertinence.Methods RT-PCR and immunohistochemical analysis technology were used to detect E-cadherin mRNA expression and E-cadherin protein expression respectively in 56 paired HCC and non-HCC liver tissue samples and 20 normal liver tissue samples.Results 1.The level of E-cadherin expression in HCC was significantly lower than that in adjacent non-HCC liver tissue and in normal liver tissue(P<0.05);but no difference was seen between adjacent non-HCC liver tissue and normal liver tissue;2.E-cadherin expression in HCC had a positive correlation with recurrence after surgical treatment(P<0.05) and an inverse correlation with pathological grade(P<0.05);3.There was an inverse correlation between E-cadherin expression in HCC and extrahepatic metastasis(P<0.05);4.Significant positive correlations were found among E-cadherin expression in adjacent non-HCC liver tissue and extrahepatic metastasis(P<0.05).Conclusion Loss and downregulation of E-cadherin have an correlation with degree of tumor differentiation,capability of invasion and metastasis and tendency of recurrence,which may have some instructive significance for the assessment of outcome of HCC. |
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| Keywords: | E-Cadherin Hepatocellular carcinoma invasion and metastasis |
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