Increased Leptin Expression in Mice with Bacterial Peritonitis is Partially Regulated by Tumor Necrosis Factor Alpha |
| |
| Authors: | Armin K. Moshyedi Michael D. Josephs Eddie K. Abdalla Sally L. D. MacKay Carl K. Edwards III Edward M. Copeland III Lyle L. Moldawer |
| |
| Affiliation: | Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610,1. and Amgen, Inc., Boulder, Colorado 803012. |
| |
| Abstract: | Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-α) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-α in peritonitis, but the anorexia is not dependent on increased leptin production. |
| |
| Keywords: | |
|
|
