| 依那普利联用叶酸治疗H型高血压的临床疗效及对血管内皮功能的影响 |
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| 引用本文： | 陈慧,徐群威. 依那普利联用叶酸治疗H型高血压的临床疗效及对血管内皮功能的影响[J]. 中华全科医学, 2017, 15(5): 805. DOI: 10.16766/j.cnki.issn.1674-4152.2017.05.023 |
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| 作者姓名： | 陈慧 徐群威 |
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| 作者单位： | 台州市中西医结合医院心内科, 浙江 温岭 317523 |
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| 摘 要： | 目的 分析与探讨采用依那普利联合叶酸治疗H型高血压患者的疗效,并研究其对患者血管内皮功能的影响。 方法 选取2014年10月-2015年10月收治的170例H型高血压患者,按照随机数字法随机分为观察组和对照组,每组85例,对照组给予马来酸依那普利片进行治疗,观察组在对照组基础上给予叶酸片进行治疗,比较2组治疗前及治疗24周后动态血压、同型半胱氨酸(Hcy)、血浆可溶性细胞间黏附分子1(sICAM-1)、颈动脉内中膜厚度(IMT)、血管内皮素(ET-1)、一氧化氮(NO)的变化情况。 结果 治疗后2组24hSBP、24hDBP、dSBP、dDBP、nSBP、nDBP、24hSBPV、24hDBPV、dSBPV、dDBPV、nSBPV、nDBPV均下降(P<0.05),观察组下降明显(P<0.05)。治疗后观察组Hcy[(7.4±2.9)μmol/L]、sICAM-1[(342.4±39.5)μg/L]、NO[(78.4±9.1)μmol/L]、ET-1[(53.4±9.6)ng/L]以及IMT[(1.0±0.6) mm]明显优于对照组[Hcy(9.2±3.0)μmol/L、sICAM-1(366.5±39.5)μg/L、NO(75.3±8.0)μmol/L、ET-1(57.4±9.8)ng/L以及IMT(1.3±0.6) mm],差异有统计学意义(P<0.05)。 结论 依那普利联用叶酸治疗更有利于改善H型高血压患者的血压及血压变异性,延缓动脉粥样硬化进程,改善血管内皮细胞功能,值得临床推广。
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| 关 键 词： | 依那普利 叶酸 H型高血压 血管内皮功能 |
| 收稿时间： | 2016-10-31 |
Clinical efficacy and enalapril combined with folic acid in the treatment of H-type hypertension and its influence on vascular endothelial function |
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| Affiliation: | Department of Cardiology, Taizhou TCM-WM Hospital, Wenling, Zhejiang 317523, China |
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| Abstract: | Objective To evaluate the clinical efficacy of enalapril combined with folic acid in the treatment of H type hypertension and its influence on vascular endothelial function. Methods From October,2014 to October,2015,170 cases of H type hypertension patients in our hospital were selected and randomly divided into the observation group and the control group (85 cases in each group);The control group were given enalapril maleate tablets,while the observation group had folic acid tablets on basis of the control group;Before and 24 w after the treatment,the 24 h ambulatory blood pressure,the levels of Hcy,sICAM-1,IMT,ET-1 and NO were tested and compared. Results After the treatment,24hSBP,24hDBP,dSBP,dDBP,nSBP,nDBP,24hSBPV,24hDBPV,dSBPV,dDBPV,nSBPV and nDBPV were all significantly decreased in both groups (P<0.05),more significantly in the observation group (P<0.05).After the treatment,the levels of Hcy,sICAM-1,NO,ET-1 and IMT were (7.4±2.9)μmol/L,(342.4±39.5)μg/L,(78.4±9.1)μmol/L,(53.4±9.6) ng/L and (1.0±0.6) mm,respectively,which were obviously superior to the control group[(9.2±3.0)μmol/L,(366.5±39.5)μg/L,(75.3±8.0)μmol/L,(57.4±9.8) ng/L and (1.3±0.6) mm,respectively],the difference was statistically significant (P<0.05). Conclusion Enalapril combined with folic acid can improve blood pressure and blood pressure variability in patients with H-type hypertension,which could delay the process of atherosclerosis and improve vascular endothelial function,worthy of clinical promotion. |
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