| 胃癌骨转移的临床特点 |
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| 引用本文： | 张高嘉①, 王俊锋①, 李万荣①, 张云鹏①, 沈志祥②. 胃癌骨转移的临床特点[J]. 中国肿瘤临床, 2015, 42(9): 457-459. DOI: 10.3969/j.issn.1000-8179.20150049 |
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| 作者姓名： | 张高嘉① 王俊锋① 李万荣① 张云鹏① 沈志祥② |
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| 作者单位： | 作者单位:①天津医科大学肿瘤医院腹部肿瘤科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室(天津市 300060);②上海交通大学医学院瑞金医院血液科 |
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| 摘 要： | 据文献报道胃癌伴有骨转移发生率为0.46% ～38% ，胃癌伴骨转移的高危因素包括：年轻患者、病理为低分化腺癌、Borrmann Ⅲ型、浸润深度T 3 和T 4、伴多发淋巴转移和胃体部肿瘤。转移途径半数以上为非门脉系统。胃癌伴骨转移而无肝转移病例占69% ，骨转移与淋巴转移区站转移有密切关联，距胃原发病灶3 cm以上存在淋巴转移者，其骨转移发生率为27% 。核素扫描为骨转移提供了诊断途径和可靠的依据，HCG 、CEA 肿瘤标志物检测对诊断骨转移有所帮助，治疗以放化疗为主。骨转移预后较差，大多生存期< 6 个月。
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| 关 键 词： | 胃癌 低分化腺癌 骨转移 转移途径 |
| 收稿时间： | 2015-01-09 |
| 修稿时间： | 2015-03-31 |
Clinical characteristics of bone metastasis from gastric cancer |
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| Gaojia ZHANG1, Junfeng WANG1, Wanrong LI1, Yunpeng ZHANG1, Zhixiang SHEN2. Clinical characteristics of bone metastasis from gastric cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(9): 457-459. DOI: 10.3969/j.issn.1000-8179.20150049 |
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| Authors: | Gaojia ZHANG1 Junfeng WANG1 Wanrong LI1 Yunpeng ZHANG1 Zhixiang SHEN2 |
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| Affiliation: | 1Department of Abdominal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin300060, China |
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| Abstract: | The bone is a common site of metastasis for gastric cancer. High- risk factors of metastatic gastric cancer include young age, poorly differentiated adenocarcinoma, Borrmann type III tumors, depth of invasion at Se and Pm levels, positive lymph nodes, and gastric cancer with concomitant body of stomach cancer. More than half of the transfer pathway belongs to the non-portal system. Cases of gastric cancer with bone metastasis but without liver metastasis accounted for 69% of the total gastric cancer cases, whereas the incidence rate of bone metastasis with lymph node metastasis (≥ 3 cm away from the primary lesion) was 27%. In addition to the tumor markers human chorionic gonadotropin and carcinoembryonic antigen, radionuclide scan of the bone metastasis provides diagnostic pathways and reliable basis for treatment. Chemoradiation and surgery as symptomatic treatments are alternative therapies for stomach cancer. Bone metastasis confers unfavorable prognosis, and the survival time is often less than six months. |
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| Keywords: | gastric cancer poorly differentiated adenocarcinoma bone metastasis route of metastases |
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