| 氯米芬联合人绝经期促性腺激素对多囊卵巢综合征患者促排卵的效果分析 |
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| 引用本文： | 纵艳艳. 氯米芬联合人绝经期促性腺激素对多囊卵巢综合征患者促排卵的效果分析[J]. 中华全科医学, 2017, 15(5): 820-822. DOI: 10.16766/j.cnki.issn.1674-4152.2017.05.028 |
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| 作者姓名： | 纵艳艳 |
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| 作者单位： | 天台中医院妇产科, 浙江 台州 317200 |
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| 摘 要： | 目的 研究氯米芬联合人绝经期促性腺激素(human menopausal gonadotropin,HMG)对多囊卵巢综合征妇女促排卵的临床疗效。 方法 选择2014年1月-2015年6月于浙江天台中医院妇产科门诊就诊的多囊卵巢综合征患者100例,按照随机数字法将患者分为2组,对照组和观察组各50例。2组患者均给予常规治疗,调整生活方式,补充钙剂和维生素D,口服炔雌醇环丙孕酮片3个月;有糖尿病患者同时服用二甲双胍。对照组给予氯米芬治疗,观察组在对照组基础上给予HMG。对比2组患者的排卵情况(卵巢体积、优质卵泡数和窦卵泡数目)、内分泌指标睾酮(T)、黄体生成素(luteinizing hormone,LH)、卵泡生成素(follicle-stimulating hormone,FSH)、妊娠情况(妊娠率、流产率和多胎妊娠率)和不良反应。 结果 观察组患者卵巢体积、窦卵泡数目显著少于对照组(8.39±0.74比11.01±1.08;7.23±0.76比9.44±0.83),差异有统计学意义(P<0.01);但优质卵泡数2组比较,差异无统计学意义(P>0.05)。观察组患者FSH、T和LH水平显著低于对照组(P<0.01)。观察组妊娠率为38.00%,显著高于对照组的20.00%,差异有统计学意义(P<0.05),2组间流产率、多胎妊娠率差异无统计学意义(P>0.05)。2组间不良反应差异无统计学意义(P>0.05)。 结论 氯米芬联合HMG对多囊卵巢综合征妇女促排卵的效果肯定。
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| 关 键 词： | 氯米芬 人绝经期促性腺激素 多囊卵巢综合征 促排卵 |
| 收稿时间： | 2016-11-15 |
Effect of clomiphene citrate with human menopausal gonadotropin on ovulation induction in women with polycystic ovary syndrome |
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| Affiliation: | Department of Obstetrics and Gynecology, Tiantai Hospital of Traditional Chinese Medicine, Taizhou, Zhejiang 317200, China |
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| Abstract: | Objective To study the effect of clomiphene citrate with human menopausal gonadotropin (HMG) on ovulation induction in women with polycystic ovary syndrome. Methods Total 100 patients with polycystic ovary syndrome in our hospital between January,2014 and June,2015 were enrolled and divided into control group and observation group with 50 cases in each group.All patients received conventional treatment,lifestyle modification,calcium and vitamin D,oral ethinylestradiol cyproterone tablet for 3 months;oral metformin treatment for the patients with diabetes.The control group received clomiphene citrate treatment,while the observation group received additional HMG treatment.The ovulation (ovarian volume,high quality follicle number and number of sinus follicle),endocrine (T,LH,FSH),pregnancies (pregnancy rate,miscarriage rate and the rate of multiple pregnancy) and adverse reactions were compared between the two groups. Results The ovarian volume and the number of sinus follicle of the observation group were significantly less than those of the control group (8.39±0.74 vs.11.01±1.08;7.23±0.76 vs.9.44±0.83),the difference was statistically significant (P<0.01),but there was no significant difference in high quality follicle number between the two groups (P>0.05).The levels of FSH,LH and T in the observation group were significantly lower than those in the control group (P<0.01).The pregnancy rate in the observation group was significantly higher than that in the control group (38.00% vs.20.00%),the difference was statistically significant (P<0.05),but in the abortion rate and multiple pregnancy rate was not statistical significance (P>0.05).The differences in adverse reactions between the two groups was not statistical significance (P>0.05). Conclusion Clomiphene citrate with HMG for polycystic ovary syndrome can stimulate ovulation with a good effect. |
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