| 功能纳米材料在肿瘤光学治疗中的应用 |
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| 引用本文： | 程亮,汪超,刘庄. 功能纳米材料在肿瘤光学治疗中的应用[J]. 中国肿瘤临床, 2014, 41(1): 18-26. DOI: 10.3969/j.issn.1000-8179.20131829 |
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| 作者姓名： | 程亮 汪超 刘庄 |
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| 作者单位： | 苏州大学功能纳米与软物质研究院（江苏省苏州市 215123） |
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| 基金项目： | 国家自然科学基金项目51302180国家自然科学基金项目51222203国家自然科学基金项目51002100国家自然科学基金项目51132006国家973项目2011CB911002国家973项目2012CB932601江苏省自然科学基金BK20130005江苏省自然科学基金BK20130305 |
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| 摘 要： | 目前在癌症的治疗中，药物化疗和手术对正常的组织易产生一定程度的损伤，且治疗效果有较大局限。肿瘤光学治疗主要采用近红外光有选择性地杀死肿瘤细胞，不会对正常的组织造成明显的不良作用。随着纳米材料和纳米科技的发展，肿瘤光学治疗如光热治疗、光动力治疗和光促进联合治疗等得到了快速的发展。本综述总结了近年来功能纳米材料在肿瘤光学治疗应用中的最新进展。
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| 关 键 词： | 肿瘤光学治疗 纳米材料 光热治疗 光动力治疗 |
| 收稿时间： | 2013-09-28 |
Functional nanomaterials for phototherapies of cancer |
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| Affiliation: | Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China |
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| Abstract: | Current cancer therapies, including chemotherapies and radiotherapies, can induce toxic side effects to normal tissues with low specificity to cancer cells and usually have limited efficacy as results of drug resistance. Phototherapies kill cancer cells under irradiation of light, preferably near-infrared light with high tissue penetration, and would normally show little toxic effect in the dark. Over the past decade, nanomaterial-based phototherapies have made tremendous progress worldwide. These therapies show remarkable results against cancer in many preclinical studies. This study reviews the recent achievements in the use of functional nanomaterials for photothermal therapy, photodynamic therapy, and photo-controlled therapeutic platforms and discusses future prospects and challenges in this field. |
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