| CDK6 导致肿瘤的机制研究进展* |
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| 引用本文： | 董一楠, 张新伟, 魏枫. CDK6 导致肿瘤的机制研究进展*[J]. 中国肿瘤临床, 2015, 42(19): 973-977. DOI: 10.3969/j.issn.1000-8179.2015.19.661 |
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| 作者姓名： | 董一楠 张新伟 魏枫 |
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| 作者单位： | 作者单位:①天津医科大学肿瘤医院肿瘤研究所免疫研究室,国家肿瘤临床医学研究中心,天津市肿瘤免疫与生物治疗重点实验室(天津市 300060) |
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| 摘 要： | 细胞周期的异常调控导致细胞过度增殖是人类肿瘤发生的重要原因之一，目前已发现CDK 6 和CDK 4 是细胞周期的重要调控因子，促进细胞周期正向进行，且在人类大多数肿瘤中过度激活，与肿瘤的发生密切相关。最近，研究证实以CDK 4/ 6 为靶点的肿瘤治疗有广泛前景。但是对于CDK 6 过度激活导致肿瘤发生的机制尚不完全清楚。因此有必要进一步了解CDK 4/ 6 在细胞周期调控通路、细胞分化中的作用及其在不同类型肿瘤中的异常表达，对深入了解肿瘤的发生机制及治疗有重大意义。本文拟对CDK 6 的结构、生物学功能、促进肿瘤的相关机制，以及其抑制剂的临床应用等方面的内容进行阐述。
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| 关 键 词： | CDK 6 肿瘤 细胞周期 细胞分化 抑制剂 |
| 收稿时间： | 2015-06-18 |
| 修稿时间： | 2015-09-14 |
Research advances in the mechanism and role of CDK6 in tumorigenesis |
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| Yinan DONG, Xinwei ZHANG, Feng WEI. Research advances in the mechanism and role of CDK6 in tumorigenesis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(19): 973-977. DOI: 10.3969/j.issn.1000-8179.2015.19.661 |
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| Authors: | Yinan DONG Xinwei ZHANG Feng WEI |
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| Affiliation: | Cell Immunology Lab, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Immunology and Cancer Biotherapy, Tianjin 300060, China. |
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| Abstract: | Cell- cycle deregulation leading to excessive cell proliferation is an important mechanism of human tumorigenesis. CDK6 and CDK 4 have been found to be significant regulators of cell cycle, particularly in promoting cell- cycle progress. Moreover, these proteins are usually overly active in most tumors and closely related to tumor development. Recently, research has confirmed CDK4/6 as prospective targets for cancer therapy. However, the mechanism of excessive CDK6 activation leading to tumorigenesis is not completely understood. Therefore, further understanding of the role of CDK4/6 in cell-cycle regulatory pathways and cell differentiation is essential, as well as their overexpression in different types of tumors. This information will elucidate the mechanisms of tumor development and treatment. Therefore, this review intends to discuss the structure and biological function of CDK 6, the role and mecha-nism of CDK6 in carcinogenesis, and the clinical application of CDK 6 inhibitors. |
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| Keywords: | CDK6 cancer cell cycle cell differentiation inhibitor |
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