| 安徽省阜阳市HIV/HCV共感染者抗病毒治疗服药依从性及影响因素分析 |
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| 引用本文： | 范引光, 朱志伟, 马炜祥, 丁志强, 程国金, 戴色莺, 叶冬青. 安徽省阜阳市HIV/HCV共感染者抗病毒治疗服药依从性及影响因素分析[J]. 中华疾病控制杂志, 2017, 21(12): 1204-1208. doi: 10.16462/j.cnki.zhjbkz.2017.12.005 |
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| 作者姓名： | 范引光 朱志伟 马炜祥 丁志强 程国金 戴色莺 叶冬青 |
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| 作者单位： | 1. 安徽医科大学公共卫生学院流行病与卫生统计学系, 安徽 合肥 230032;;;2. 阜阳市京九区卫生站, 安徽 阜阳 236000;;;3. 安徽省疾病预防控制中心艾滋病防治科, 安徽 合肥 230000 |
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| 基金项目： | 安徽省自然科学基金（1608085MH174）；省级质量工程研究项目（2016jxxm0522）；国家级大学生创新创业项目（201710366028） |
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| 摘 要： | 目的 探讨安徽省人类免疫缺陷病毒（human immunodeficiency virus，HIV）/丙型肝炎病毒（hepatitis C virus，HCV）共感染者抗病毒治疗服药依从性现状及其影响因素，为制定综合管理策略提供理论依据。方法 采用横断面研究方法，对安徽省阜阳市接受抗病毒治疗1年以上的HIV/HCV共感染者进行问卷调查，收集患者的一般信息和服药情况，采用多因素Logistic回归分析对其服药依从性的影响因素进行分析。结果 256例HIV/HCV共感染者在过去1个月内抗病毒治疗的服药不依从率为34.0%，结婚年限较长（OR=3.049，95%CI：1.435~6.481，P=0.004）、抗病毒治疗时间较长（OR=1.803，95%CI：1.251~2.599，P=0.002）和饮酒者（OR=2.512，95%CI：1.152~5.478，P=0.021）抗病毒治疗依从性较差，而女性（OR=0.180，95%CI：0.089~0.366，P<0.001）和设置服药提醒者（OR=0.315，95%CI：0.159~0.626，P=0.001）的抗病毒治疗依从性较好。结论 降低社会公众的艾滋病歧视和提高HIV/HCV共感染者抗病毒治疗的信心，是改善抗病毒治疗服药依从性的关键。
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| 关 键 词： | HIV 获得性免疫缺陷综合征 肝炎病毒 抗病毒药 |
| 收稿时间： | 2017-06-20 |
| 修稿时间： | 2017-09-10 |
Study on influencial factors of adherence to anti-retroviral treatment among people who co-infected with HIV/HCV in Fuyang City,Anhui Province |
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| FAN Yin-guang, ZHU Zhi-wei, MA Wei-xiang, DING Zhi-qiang, CHENG Guo-jin, DAI Se-ying, YE Dong-qing. Study on influencial factors of adherence to anti-retroviral treatment among people who co-infected with HIV/HCV in Fuyang City, Anhui Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2017, 21(12): 1204-1208. doi: 10.16462/j.cnki.zhjbkz.2017.12.005 |
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| Authors: | FAN Yin-guang ZHU Zhi-wei MA Wei-xiang DING Zhi-qiang CHENG Guo-jin DAI Se-ying YE Dong-qing |
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| Affiliation: | 1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China;;;2. Health Station of Jingjiu District, Fuyang City, Fuyang 236000, China;;;3. AIDS Department of Anhui Provincial Center for Disease Control and Provention, Hefei 230000, China |
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| Abstract: | Objective To investigate the adherence to anti-retroviral treatment and related factors among human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infectors. Methods In this cross-sectional study, 256 HIV and HCV co-infectors were recruited by convenience sampling method, and information about demography, taking medicine and therapy were collected and analyzed. Results A total of 256 HIV/HCV co-infectors were investigated, 34.0% of them missed dose in the last month. Multiple Logistic regression analysis showed that HIV/HCV co-infectors with long marriage (OR=3.049, 95% CI:1.435-6.481, P=0.004), longer time of treatment with antiretroviral therapy (ART) (OR=1.803, 95% CI:1.251-2.599, P=0.002), frequent alcohol consumption (OR=2.512, 95% CI:1.152-5.478, P=0.021) were risk factors of missed dose, while female (OR=0.180, 95% CI:0.089-0.366, P<0.001) and co-infectors who take a reminder method (OR=0.315, 95% CI:0.159-0.626, P=0.001) were protective factors for missed dose. Conclusions The ART adherence rate of HIV/HCV co-infectors was lower in Anhui Province, comprehensive intervention measures should be taken to promote the ART adherence. |
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| Keywords: | HIV Acquired immunodeficiency syndrome Hepatitis viruses Antiviral agents |
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