| 放疗与免疫治疗联合应用的相关机制及研究进展 |
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| 引用本文： | 于金明,滕菲菲. 放疗与免疫治疗联合应用的相关机制及研究进展[J]. 中国肿瘤临床, 2014, 41(9): 547-550. DOI: 10.3969/j.issn.1000-8179.20140527 |
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| 作者姓名： | 于金明 滕菲菲 |
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| 作者单位： | 山东省肿瘤防治研究院放疗科（济南市 250017） |
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| 基金项目： | 中国工程院咨询研究项目YY7 |
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| 摘 要： | 放疗主要通过对放射野内肿瘤细胞的杀伤来提高肿瘤的局部控制、降低远处播散并能够激活机体抗肿瘤免疫应答，在免疫治疗的辅助下发挥全身抗肿瘤的作用。放疗联合免疫治疗作为一种新的治疗方式在部分转移性癌症患者中取得了显著疗效。在放射线杀伤局部肿瘤细胞的过程中，肿瘤相关抗原释放表达增加、肿瘤免疫抑制微环境得到改善、激活特异性T细胞免疫应答促使肿瘤细胞形成原位疫苗，合适的放疗剂量与分割模式在最佳时机联合相应的免疫治疗可杀伤放疗野外的远处转移病灶。本文对放疗促进抗肿瘤免疫反应的具体机制以及两者联合应用的广阔前景和面临的挑战进行综述。
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| 关 键 词： | 肿瘤 放射治疗 免疫治疗 |
| 收稿时间： | 2014-03-25 |
Mechanisms and challenges in joint application of radiotherapy and cancer immunotherapy |
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| Affiliation: | Department of Radiation Oncology, Shandong Tumor Hospital and Institute, Shandong University, Jinan 250017, China |
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| Abstract: | The effects of radiotherapy (RT) on the survival of cancer patients are interpreted as a consequence of the improved local control of tumors that directly decrease systemic spreading. Some of the effects of ionizing radiation are recognized as a contribution to systemic antitumor immunity, which can provide sufficient evidence for proposing a paradigm shift. Recent examples of objective responses achieved by adding radiotherapy to immunotherapy in metastatic cancer patients support this view. Preclinical data indicate that RT can convert irradiated tumor into an in situ individualized vaccine and potentiate the systemic efficacy of immunotherapy, whereas activation of the innate and adaptive immune system can enhance the local efficacy of RT. This study summarizes key evidence that support the role of radiotherapy as an immune adjuvant and some of the current challenges in translating this knowledge for clinical use. |
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