Protection of mice against Listeria monocytogenes infection by recombinant human tumor necrosis factor alpha. |
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| Authors: | J V Desiderio P A Kiener P F Lin G A Warr |
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| Affiliation: | Department of Microbiology, Bristol-Myers Co., Wallingford, Connecticut 06492. |
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| Abstract: | Recombinant human tumor necrosis factor alpha (rHuTNF-alpha) administered intravenously to mice resulted in enhanced resistance to a lethal challenge infection of Listeria monocytogenes given 24 h later. The observed protection was lost following treatment of the rHuTNF-alpha preparations with rabbit polyclonal antibody rHuTNF-alpha but not with normal rabbit immunoglobulin G. |
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