Separation and Detection of Tetracyclines by High-Speed Liquid Chromatography |
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| Authors: | A. G. Butterfield D. W. Hughes N. J. Pound W. L. Wilson |
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| Affiliation: | Drug Research Laboratories, Health Protection Branch, Department of National Health and Welfare, Ottawa, Ontario, Canada |
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| Abstract: | The high-speed liquid chromatographic behavior of 15 tetracyclines on anion- and cation-exchange columns is described and illustrated by typical separations of a number of tetracycline derivatives on several systems, as well as by the resolution of tetracycline from its degradation products epi-, epianhydro-, and anhydrotetracycline. These serve as a basis for a rapid, convenient, and precise method for the direct detection of the tetracycline antibiotics and their degradation products. |
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