| 正常昆明种与NIH种小鼠自然发生微核率的比较 |
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| 引用本文： | 李欣,梁雪梅,张静,杨颖,李志,黄俊明,雄习昆. 正常昆明种与NIH种小鼠自然发生微核率的比较[J]. 癌变．畸变．突变, 2003, 15(3): 168-170. DOI: 10.3969/j.issn.1004-616x.2003.03.012 |
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| 作者姓名： | 李欣 梁雪梅 张静 杨颖 李志 黄俊明 雄习昆 |
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| 作者单位： | 广东省疾病预防控制中心毒理所, 广东 广州 510300;广东省疾病预防控制中心毒理所, 广东 广州 510300;广东省疾病预防控制中心毒理所, 广东 广州 510300;广东省疾病预防控制中心毒理所, 广东 广州 510300;广东省疾病预防控制中心毒理所, 广东 广州 510300;广东省疾病预防控制中心毒理所, 广东 广州 510300;广东省疾病预防控制中心毒理所, 广东 广州 510300 |
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| 摘 要： | 目的： 比较正常昆明种与NIH种小鼠胸骨骨髓嗜多染红细胞微核的自然发生率。 方法： 按《食品安全性毒理学评价程序和方法》采用30 h法微核试验,计数微核数,计算微核率。 结果： 小鼠胸骨骨髓PCE自然发生率呈正偏态分布,中位数能较好的代表其平均水平,昆明种小鼠胸骨骨髓PCE微核自然发生率(‰),雌鼠为1.0(0, 4.0),雄鼠为2.0(0, 6.0),性别间差异有统计学意义(P<0.05);NIH种小鼠胸骨骨髓PCE微核数自然发生率(‰),雌鼠为2.0(0, 3.0),雄鼠为2.0(0, 6.0),性别间差异无统计学意义。昆明种和NIH种小鼠胸骨骨髓PCE自发微核率间差异无统计学意义。 结论： 昆明种与NIH种小鼠胸骨骨髓PCE微核的自然发生率与其他人的研究较接近,昆明种与NIH种小鼠品系间差异无统计学意义,而昆明种小鼠性别间差异有统计学意义。
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| 关 键 词： | 微核 昆明种小鼠 NIH种小鼠 |
| 文章编号： | 1004-616X(2003)03-0168-03 |
| 收稿时间： | 2002-08-29 |
| 修稿时间： | 2002-08-29 |
A COMPARISON OF NATURAL MICRONUCLEUS FREQUENCIES IN POLYCHROMATIC ERYTHROCYTES BETWEEN KUNMING MICE AND NIH MICE |
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| LI Xin,LIANG Xue-mei,ZHANG Jing,et al. A COMPARISON OF NATURAL MICRONUCLEUS FREQUENCIES IN POLYCHROMATIC ERYTHROCYTES BETWEEN KUNMING MICE AND NIH MICE[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2003, 15(3): 168-170. DOI: 10.3969/j.issn.1004-616x.2003.03.012 |
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| Authors: | LI Xin LIANG Xue-mei ZHANG Jing et al |
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| Affiliation: | Lab of Genetic Toxicology, Center of Disease Control and Prevention of Guangdong Province, Guangzhou 510300, China |
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| Abstract: | Purpose: To compare natural micronucleus frequencies in polychromatic erythrocytes (fMPCE) from normal Kunming mouse ch est bone marrow to that from normal NIH strain. Methods: Acc ording to Procedures and methods for toxicological assessment on food safety, 30 h micronucleus test was performed, the numb ers of micronuclei were scored, and the fMPCE was calculated. Results: The natural fMPCE from the chest bone marrow showed skew distribution, and the media was a good indicator. The natural fMPCE of Kunming mice was 1.0 (0, 4.0) in female, a nd 2.0 (0, 6.0) in male, and there was a significant differe nce between different sex (P<0.05). The natural fMPCE of NIH mice was 2.0 (0, 4.0) in female, 2.0 (0, 6.0 ) in male, and there was no significant difference between d ifferent sex. There was no significant difference between Kunmin g and NIH mice in the natural fMPCE. Conclusion: The natural fMPCE from chest bone marrow of Kunming mice and NIH mice are similar. There is no significant difference between two strains; but a significant difference between different sex in Kunming mice does exist (P<0.05). |
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| Keywords: | micronucleus kunming mouse NIH mouse |
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