| 外源性IL-10对炎症牙龈组织中IL-6和ICAM-1表达的影响 |
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| 引用本文： | 杨丕山,赵民,戚向敏,葛少华. 外源性IL-10对炎症牙龈组织中IL-6和ICAM-1表达的影响[J]. 华西口腔医学杂志, 2002, 20(5): 343-345 |
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| 作者姓名： | 杨丕山 赵民 戚向敏 葛少华 |
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| 作者单位： | 250012 山东大学口腔医学院(杨丕山,戚向敏,葛少华),济南军区第106医院(赵 民) |
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| 摘 要： | 目的:探讨外源性IL-10对炎症牙龈组织中IL-6和细胞间粘附分子-1(ICAM-1)表达的影响。方法:采用免疫组化技术检测牙周袋内用或不用IL-10时成人牙周炎患者牙龈组织中IL-6和ICAM-1的表达。结果:IL-6和ICAM-1 均可在炎症牙龈组织的多种细胞表达。IL-6主要表达于淋巴细胞、单核)巨噬细胞、成纤维细胞和内皮细胞。I- CAM-1主要表达于淋巴细胞、上皮细胞、单核)巨噬细胞、成纤维细胞和内皮细胞。使用Image-Proplus软件系统测得的IL-6和ICAM-1表达的IOD值在实验组和对照组间有显著性差异(P<0105)。结论:外源性IL-10对炎症牙龈组织中IL-6和ICAM-1的表达有下调作用。
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| 关 键 词： | 细胞因子 牙龈组织 成人牙周炎 免疫组织化学 |
| 收稿时间： | 2002-10-25 |
| 修稿时间： | 2001-01-18 |
Effects of Exogenous IL-10 on IL-6 and ICAM-1 Expression in Inflammatory Gingival Tissue |
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| Yang Pishan,Qi Xiangmin,Ge ShaohuaCollege of Stomatology,Shandong UniversityZhao MinThe Hospital of PLA,Jinan. Effects of Exogenous IL-10 on IL-6 and ICAM-1 Expression in Inflammatory Gingival Tissue[J]. West China journal of stomatology, 2002, 20(5): 343-345 |
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| Authors: | Yang Pishan Qi Xiangmin Ge ShaohuaCollege of Stomatology Shandong UniversityZhao MinThe Hospital of PLA Jinan |
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| Affiliation: | Yang Pishan, Qi Xiangmin, Ge Shaohua College of Stomatology, Shandong University ZhaoMin The 106 Hospital of PLA, Jinan |
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| Abstract: | Objective:This study aimed at investigating effects of exogenous interleukine-10 (IL-10) on IL-6 and intercellular adhesion molecular (ICAM-1) expression in inflamed gingival tissue.Methods: The expression of IL-6 and ICAM-1 was examined using immunohistochemical techniques. Inflammatory gingival tissue treated with IL-10 was taken as the experimental group and the same patient's inflammatory gingival tissue without treatment of IL-10 was included into the control group.Results:IL-6 expression was found mainly in monocytes, macrophages, lymphocytes, endotheliocytes and fibroblasts. The expression of ICAM-1 was found mainly in epithelial cells, monocot-macrophages, lymphocytes, endotheliocytes and fibroblasts. The immunohistochemical optical density (IOD) of the expression of IL-6 and ICAM-1 was detected by using Image-Proplus software, and the results showed that the expression in the experimental group differed significantly from that in the control group.Conclusion:The exogenous IL-10 may down-regulate IL-6 and ICAM-1 expression in inflammatory gingival tissue. |
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| Keywords: | interlukine-10 gingival tissue interlukine-6 intercellular adhesion molecular immunohistochemistry |
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