In vitro development of resistance to human immunodeficiency virus protease inhibitor GW640385 |
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| Authors: | Yates P J Hazen R St Clair M Boone L Tisdale M Elston R C |
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| Affiliation: | UK Virology, GlaxoSmithKline Inc., Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom. pjy29430@gsk.com |
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| Abstract: | Development of in vitro resistance to GW640385, a new human immunodeficiency virus type 1 protease inhibitor, was studied. Variants characterized included one with <4-fold resistance and amino acid substitutions Q58E/A71V (protease) and P452K (Gag) and one with >50-fold resistance and amino acid substitutions L10F/G16E/E21K/A28S/M46I/F53L/A71V (protease) and L449F/P453T (Gag). The A28S substitution substantially reduced replication capacity. |
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