| 新型冠状病毒疫苗对新型冠状病毒德尔塔变异株预防效果的Meta分析 |
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| 引用本文： | 袁欣鑫1,韦焘1,张许生2,李志波1,熊欢1,孙艳春1,庞林鸿1,李海东1,刘伟1. 新型冠状病毒疫苗对新型冠状病毒德尔塔变异株预防效果的Meta分析[J]. 现代预防医学, 2022, 0(17): 3216-3221. DOI: 10.20043/j.cnki.MPM.202111059 |
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| 作者姓名： | 袁欣鑫1 韦焘1 张许生2 李志波1 熊欢1 孙艳春1 庞林鸿1 李海东1 刘伟1 |
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| 作者单位： | 1.昆明医科大学公共卫生学院,云南 昆明 650000;2.英格兰公共卫生署传染病监测及控制中心 |
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| 摘 要： | 目的 运用循证医学Meta分析方法,探究和评价新型冠状病毒疫苗对新型冠状病毒德尔塔变异株的预防效果,为新冠肺炎的防控提供循证支持。方法 以新型冠状病毒德尔塔毒株、疫苗及其同义词、近义词作为检索词,系统检索中国知网、万方数据库、维普数据库、中国生物医学文献服务系统、PubMed、考科蓝图书馆、Web of Science、BioRxiv、MedRxiv和Europe PMC关于新型冠状病毒疫苗保护效果(Vaccine Effectiveness,VE)的文献,使用纽卡斯尔-渥太华风险评分量表对纳入的队列研究和病例对照研究文献进行质量评价,对纳入的随机对照试验则使用Jadad评分进行质量评价,运用Stata 12.0进行异质性检验、总效应值和发表性偏倚估计。结果 共纳入文献14篇,其中病例对照研究文献5篇,队列研究文献8篇,随机对照实验1篇。Meta分析显示,接种一剂新冠疫苗的合并VE(95%CI)为34.57%(95%CI:21.70%～47.44%),接种两剂新型冠状病毒疫苗的合并VE(95%CI)为70.56%(95%CI: 64.29%～76.82%)。漏斗图分析表明存在发表偏倚风险。结论 接种新型冠状病毒疫苗对预防新型冠状病毒德尔塔变异株有保护作用,且2剂疫苗保护作用明显比1剂疫苗强。后续仍需要收集更多的疫苗保护率研究,提供发表性偏倚风险小的证据。
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| 关 键 词： | 新型冠状病毒疫苗 新型冠状病毒德尔塔变异株 Meta分析 |
Vaccine effectiveness for delta variants of SARS-CoV-2: a Meta analysis |
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| YUAN Xin-xin,WEI Tao,ZHANG Xu-sheng,LI Zhi-bo,XIONG Huan,SUN Yan-chun,PANG Lin-hong,LI Hai-dong,LIU Wei. Vaccine effectiveness for delta variants of SARS-CoV-2: a Meta analysis[J]. Modern Preventive Medicine, 2022, 0(17): 3216-3221. DOI: 10.20043/j.cnki.MPM.202111059 |
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| Authors: | YUAN Xin-xin WEI Tao ZHANG Xu-sheng LI Zhi-bo XIONG Huan SUN Yan-chun PANG Lin-hong LI Hai-dong LIU Wei |
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| Affiliation: | *School of Public Health,Kunming Medical University,Kunming,Yunnan 650000,China |
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| Abstract: | Objective To estimate the vaccine effectiveness(VE)for infection and provide evidence-based support for prevention and control with delta variants of SARS-CoV-2. Methods Delta variants of SARS-CoV-2, vaccine and their synonyms were used as the retrieval terms, and systematic retrieval was performed in CNKI, Wanfang Data knowledge service platform, Weipu database, SinoMed, PubMed, Cochrane Library, Web of Science, BioRxiv, MedRxiv and Europe PMC literature on the effectiveness of vaccines for infection with delta variants of SARS-CoV-2. The Newcastle Ottawa scale(NOS)was used to assess the quality of the included cohort studies and case-control studies, the Jadad scale was used to assess the quality of randomized controlled trials, and Stata 12.0 was used to test the heterogeneity, total effect value and publication bias. Results a total of 14 papers were included, including 5 case-control studies, 8 cohort studies, and 1 randomized controlled trial. Meta analysis showed that the pooled VE(95%CI)was 34.57%(95%CI: 21.70%- 47.44%)for one dose and 70.56%(95%CI: 64.29%- 76.82%)for two doses of the vaccine. Funnel plot indicated that there was a risk of publication bias. Conclusion The vaccine for infection with delta variants of SARS-CoV-2 is effective. The effectiveness of two doses of vaccine is stronger than that of the one dose. It is necessary to collect more studies in future on vaccine effectiveness to provide stronger evidence with low risk of publication bias. |
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| Keywords: | Vaccine for COVID-19 Delta variants of SARS-CoV-2 Meta analysis |
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