| 维生素C与妊娠期糖尿病关系的Meta分析 |
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| 引用本文： | 閤爽博1,' target='_blank'>2,张金娟1,' target='_blank'>2,刘菊芬1,' target='_blank'>2. 维生素C与妊娠期糖尿病关系的Meta分析[J]. 现代预防医学, 2022, 0(8): 1529-1536 |
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| 作者姓名： | 閤爽博1 ' target='_blank'>2 张金娟1 ' target='_blank'>2 刘菊芬1 ' target='_blank'>2 |
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| 作者单位： | 1北京大学生育健康研究所，国家卫生健康委员会生育健康重点实验室，北京 100191；2 北京大学公共卫生学院流行病与卫生统计学系，北京 100191 |
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| 摘 要： | 目的 系统评价维生素C（VC）暴露与妊娠期糖尿病（GDM）的相关性。 方法 检索PubMed、Embase、Cochrane Library、SinoMed、中国知网数据库从建库至2021年7月VC摄入水平或血液VC浓度与GDM关联的文献，按纳入标准筛选文献、提取资料后进行meta分析。 结果 从检索的687篇文献中筛选得到21篇文献，其中17篇质量评分为5分及以上并纳入分析（n = 11 376）。结果显示，VC低暴露组的GDM发生率显著高于高暴露组（OR = 2.46, 95%CI: 1.42～4.25），暴露浓度差距SMD = - 0.61（95%CI: - 1.13～- 0.08）。在亚组分析中，在以下分组时OR（95%CI）具有统计学意义:内暴露2.63（1.42～4.86）、外暴露2.52（1.07～5.94）、中国1.38（1.04～1.83）、欧美地区2.14（1.18～3.88）、印度4.73（1.24～18.10）、孕中期或晚期1.57（1.22～2.02）；以下分组SMD（95%CI）具有统计学意义:内暴露- 1.70（- 2.88～- 0.52）、欧美地区- 0.45（- 0.79～- 0.11）、印度- 1.84（- 3.64～- 0.04）、孕中期或晚期- 1.01（- 1.79～- 0.22）、ADA标准- 0.74（- 1.32～- 0.16），即VC低暴露时GDM发生率更高。 结论 VC低暴露是GDM的危险因素。孕妇多摄入富含VC的食物，提高血液VC浓度，有助于预防GDM的发生，促进母婴健康。
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| 关 键 词： | 维生素C 妊娠期糖尿病 膳食 血液 meta分析 |
Meta-Analysis of association between vitamin C and gestational diabetes mellitus |
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| XIA Shuang-bo,ZHANG Jin-juan,LIU Ju-fen. Meta-Analysis of association between vitamin C and gestational diabetes mellitus[J]. Modern Preventive Medicine, 2022, 0(8): 1529-1536 |
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| Authors: | XIA Shuang-bo ZHANG Jin-juan LIU Ju-fen |
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| Affiliation: | *Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Peking University, Beijing 100191, China |
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| Abstract: | Objective To evaluate the association between vitamin C (VC) exposure and gestational diabetes mellitus (GDM). Methods Pubmed, Embase, Cochrane library, SinoMed, China National Knowledge Infrastructure(CNKI) were electronically searched for studies on the association between dietary VC intake levels or blood VC concentrations and GDM from inception to July 2021. Then meta-analysis was conducted after screening literature and extracting information according to inclusion criteria. Results From the 687 articles retrieved, 21 articles were screened, 17 of which had a quality rating of 5 and above and were included in the analysis (n=11 376). Meta-analysis showed that compared with those in the high exposure group, the prevalence of GDM was significantly higher in the low VC exposure group (OR=2.46, 95%CI: 1.42 to 4.25), with an exposure concentration gap SMD=-0.61 (95%CI: -1.13 to -0.08). In the subgroup analysis, the OR (95%CI) was statistically significant at the following subgroups: in both internal exposure 2.63 (1.42 to 4.86) and external exposure 2.52 (1.07 to 5.94), in China 1.38 (1.04 to1.83), western countries 2.14 (1.18 to 3.88) and India 4.73 (1.24 to 18.10), during second and third trimesters 1.57 (1.22 to 2.02); and the following subgroups of SMD (95%CI) were statistically significant: in internal exposure -1.70 (-2.88 to -0.52), in western countries -0.45 (-0.79 to -0.11) and India -1.84 (-3.64 to -0.04), during second and third trimesters -1.01 (-1.79 to -0.22) and in ADA diagnostic criteria -0.74 (-1.32 to -0.16), which meant that the low VC exposure was significantly associated with increased GDM risk. Conclusion Low VC exposure is a risk factor for GDM. Increased intake of vitamin C-rich foods and higher blood VC concentrations in pregnant women can help prevent the development of GDM and promote maternal and infant health. |
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| Keywords: | Vitamin C Gestational diabetes mellitus Diet Blood Meta-analysis |
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