HLA class I molecules are associated with CD1a heavy chains on normal human thymus cells |
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| Authors: | M Amiot H Dastot L Degos J Dausset A Bernard L Boumsell |
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| Affiliation: | Institut National de la Santé et de la Recherche Médicale, H?pital Saint-Louis, Paris, France. |
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| Abstract: | The molecules encoded by the major histocompatibility complex play a pivotal role in regulatory interactions between cells of the immune system, which can result in the activation and function of T cells. The function of the CD1 molecules, which are homologous to the major histocompatibility complex-encoded molecules but are encoded on human chromosome 1, is not known. HLA class I molecules and CD1a heavy chains share the ability to associate with several different cell-surface molecules. We show here, by several technical approaches, that HLA class I molecules are associated with CD1a heavy chains on the surface of normal thymus cells. The functional significance of this association during T-cell differentiation is discussed. |
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