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| 基于超声粒子图像测速技术的大鼠动脉二维血流速度测量 | |
| 引用本文： | 朱懿恒,钱明,牛丽丽,郑海荣,卢广文. 基于超声粒子图像测速技术的大鼠动脉二维血流速度测量[J]. 南方医科大学学报, 2014, 34(9): 1305 |
| 作者姓名： | 朱懿恒 钱明 牛丽丽 郑海荣 卢广文 |
| 作者单位： | 1. 南方医科大学生物医学工程学院,广东广州510515;中国科学院深圳先进技术研究院,广东深圳518055 2. 中国科学院深圳先进技术研究院,广东深圳,518055 3. 南方医科大学生物医学工程学院,广东广州,510515 |
| 基金项目： | 国家自然科学基金，国家科技支撑计划资助项目，National Natural Science Foundation of China |
| 摘 要： | 目的动脉粥样硬化及血栓的形成与动脉管腔内的血流动力学参数变化密切相关。然而，目前普遍应用的超声多普勒成 像技术不能精确测量复杂血流流场信息。二维的动脉血流速度场能为心血管疾病提供重要的临床信息。方法应用超声粒子 图像测速技术，通过B型超声记录超声造影剂粒子图像，获得二维血管全流场的信息。本研究使用5组大鼠数据，计算其左侧颈 动脉的全场血流速度分布，统计3个心动周期的血流速度并与超声多普勒测速方法的结果对比。结果和结论实验结果表明，超 声粒子成像技术测速结果与超声多普勒测速结果相似。超声粒子图像测速方法的结果较超声多普勒的方法结果偏小，平均血 流速度、峰值速度误差为2%~8%和5%~10%。两种测速方法经t检验（P>0.05）无显著的统计学差异。超声粒子图像测速技术 能够无创、实时评估全流场血流动力学变化情况，通过测速可区分不同分组的大鼠。它为进一步探讨狭窄血管中复杂多变的血 流场提供新的影像学方法。 |
| 关 键 词： | 超声粒子图像测速 血流成像 血流动力学 二维血流速度 |
Two-dimensional measurement of blood flow velocity in rat arteries based on ultrasonic particle image velocimetry |
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| ZHU Yiheng,QIAN Ming,NIU Lili,ZHENG Hairong,LU Guangwen. Two-dimensional measurement of blood flow velocity in rat arteries based on ultrasonic particle image velocimetry[J]. Journal of Southern Medical University, 2014, 34(9): 1305 | |
| Authors: | ZHU Yiheng QIAN Ming NIU Lili ZHENG Hairong LU Guangwen |
| Abstract: | Objective Ultrasonic pulse wave Doppler technique for noninvasive blood flow imaging does not provide precise information of complex blood flow field, and observing two-dimensional artery blood flow field distribution provides important clinical information for cardiovascular disease. Methods Ultrasonic particle image velocimetry (Echo PIV) was used to measure blood flows on B-mode ultrasonic particle image to assess the whole field velocity of the blood vessels in 5 groups of healthy rats. The reliability of Echo PIV was verified in comparison with ultrasonic Doppler method in 3 cardiac cycles. Results and Conclusion The results of Echo PIV were similar with the those of ultrasound spectral Doppler. The Echo PIV-measured peak and average velocity within 3 cardiac cycles were about 5%-10% and 2%-8% below the values measured by the ultrasonic spectral Doppler, respectively, but these differences were not statistically significant (P>0.05). As a new technique for monitoring complex blood flow in stenotic arteries, echo PIV can be used to directly and non-invasively assess whole field hemodynamic changes in blood vessels in real time and distinguish different groups of rats by velocity. |
| Keywords: | ultrasonic particle image velocimetry blood flow imaging hemodynamics two-dimensional velocity |
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