| N-端骨钙素与老年男性2型糖尿病患者骨质疏松的相关性分析 |
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| 引用本文： | 郑桂芳,马丽华,孙志红,于树杨. N-端骨钙素与老年男性2型糖尿病患者骨质疏松的相关性分析[J]. 国际医药卫生导报, 2022, 28(5): 646-650. DOI: 10.3760/cma.j.issn.1007-1245.2022.05.013 |
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| 作者姓名： | 郑桂芳 马丽华 孙志红 于树杨 |
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| 作者单位： | 1德州市人民医院门诊部，德州 253000；2德州市人民医院骨科，德州 253000；3德州市人民医院消毒供应室，德州 253000；4德州市联合医院影像科，德州 253000 |
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| 基金项目： | 山东省医药卫生科技发展计划项目（2018WS524） |
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| 摘 要： | 目的:探讨N-端骨钙素（N-MID）与老年男性2型糖尿病（T2DM）患者骨质疏松的相关性。方法:回顾性分析2015年1月至2019年12月在德州市人民医院门诊和住院治疗的100例≥60岁男性T2DM患者的临床资料，根据骨密度（BMD）水平将患者分为非骨质疏松组（62例）和骨质疏松组（38例）。对所有患者的BMD进行测量...
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| 关 键 词： | N-端骨钙素 老年 男性 2型糖尿病 骨质疏松 |
| 收稿时间： | 2021-08-02 |
Association between N-terminal osteocalcin and osteoporosis in elderly male patients with type 2 diabetes mellitus |
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| Zheng Guifang,Ma Lihua,Sun Zhihong,Yu Shuyang. Association between N-terminal osteocalcin and osteoporosis in elderly male patients with type 2 diabetes mellitus[J]. International Medicine & Health Guidance News, 2022, 28(5): 646-650. DOI: 10.3760/cma.j.issn.1007-1245.2022.05.013 |
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| Authors: | Zheng Guifang Ma Lihua Sun Zhihong Yu Shuyang |
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| Affiliation: | 1 Outpatient Department, Dezhou People's Hospital,Dezhou 253000, China; 2 Department of Orthopedics, Dezhou People'sHospital, Dezhou 253000, China; 3 Disinfection and Supply Room,Dezhou People's Hospital, Dezhou 253000, China; 4 Department ofImaging, Dezhou Combination Hospital, Dezhou 253000, China |
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| Abstract: | Objective To investigate the association between N-terminal osteocalcin (N-MID)and osteoporosis in elderly male patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 100 male T2DM outpatientsor inpatients ≥60 years old who weretreated in Dezhou People's Hospital from January 2015 to December 2019 wereretrospectively analyzed. They were divided into a non-osteoporotic group (62cases) and an osteoporotic group (38 cases) according to their bone mineraldensities (BMD). The BMD was measured in all the patients, and the serum levelsof leptin, 25(OH)D3, bone alkaline phosphatase (BAP), procollagen type I carboxy-terminal peptide (PICP), pyridinoline cross linked carboxyterminal telopeptideof type I collagen (ICTP), β-CTX, and N-MID were also measured. The correlationanalysis between N-MID and other indicators was conducted. The risk factors forosteoporosis were analyzed by logistic regression analysis, and receiveroperating characteristics curve (ROC) were drawn to determine the diagnosticvalue of N-MID for osteoporosis. The measurement data were compared between thetwo groups by the independent-sample t test. Results The thoracic BMD,lumbar BMD, hip BMD, leptin, 25(OH)D3, BAP, and N-MID in the osteoporotic groupwere lower than those in the non-osteoporotic group (all P<0.05). The PICP, ICTP, β-CTX, and HbA1c in the osteoporoticgroup were higher than those in the non-osteoporosis group (all P<0.05). N-MID was positively correlatedwith thoracic BMD, lumbar BMD, hip BMD, leptin, 25(OH)D3, and BAP (r=0.374, 0.501, 0.428, 0.672, 0.691, and0.807; all P<0.05), and negativelywith PICP, ICTP, β-CTX, and HbA1c (r=-0.419,-0.293, -0.313, and -0.405; all P<0.05).Binary logistic regression analysis showed that N-MID was an independent riskassessment factor for the osteoporosis patients (OR=2.85, P<0.05). Thearea under the ROC for the diagnosis of osteoporosis by serum N-MID was 0.851(95%CI 0.724-0.943), so it hadcertain diagnostic value for osteoporosis (Z=4.073, P<0.001). Taking the N-MIDconcentration of 12.26 μg/ml as the diagnostic cut-off value, the sensitivityand specificity of N-MID in the diagnosis of osteoporosis were 83.93% and72.61%, respectively. Conclusion The serum N-MID levelin elderly male patients with T2DM and osteoporosis decreases, and is anindependent risk factor for osteoporosis, so it may serve as a diagnosticindicator for T2DM combined with osteoporosis in elderly men. |
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| Keywords: | N-terminal osteocalcin Old age Male Type 2 diabetes mellitus Osteoporosis |
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