| 2019冠状病毒病(COVID-19)疫情期生物样本保藏生物安全防护原则及建议 |
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| 引用本文： | 张小燕,孙伟,尚世强,毛建华,傅君芬,舒强,江克文. 2019冠状病毒病(COVID-19)疫情期生物样本保藏生物安全防护原则及建议[J]. 浙江大学学报(医学版), 2020, 49(2): 170-177. DOI: 10.3785/j.issn.1008-9292.2020.02.04 |
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| 作者姓名： | 张小燕 孙伟 尚世强 毛建华 傅君芬 舒强 江克文 |
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| 作者单位： | 浙江大学医学院附属儿童医院生物样本库中心 国家儿童健康与疾病临床医学研究中心, 浙江 杭州 310051 |
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| 基金项目： | 浙江大学新型冠状病毒（2019-nCoV）肺炎应急科研专项；国家自然科学基金(81871012) |
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| 摘 要： | 严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染引起的2019冠状病毒病（COVID-19）是乙类传染病。随着COVID-19疫情蔓延，生物样本库样本保藏的生物安全风险增加，其生物安全防护显得越来越重要。根据国家有关规定和中华医学会相关指南，本文基于SARS-CoV-2病原学和COVID-19流行病学资料，提出了生物样本采集、转运、处理、保藏、检测、检测后处置、突发事件等过程中个人和生物样本保藏场所的生物安全防护原则及若干建议。强调依据有无病毒载量信息、传染力大小、标本类型（可能接触传播、气溶胶传播、粪口途径传播）对样本进行严格的生物安全风险评估，以指导疫情期间生物样本保藏、确保生物样本库生物安全。
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| 关 键 词： | 2019冠状病毒病 严重急性呼吸综合征冠状病毒2 新型冠状病毒肺炎 生物标本库 安全管理 保存 生物学 |
| 收稿时间： | 2020-02-19 |
Principles and suggestions on biosafety protection of biological specimen preservation during prevalence of COVID-19 |
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| ZHANG Xiaoyan,SUN Wei,SHANG Shiqiang,MAO Jianhua,FU Junfen,SHU Qiang,JIANG Kewen. Principles and suggestions on biosafety protection of biological specimen preservation during prevalence of COVID-19[J]. Journal of Zhejiang University. Medical sciences, 2020, 49(2): 170-177. DOI: 10.3785/j.issn.1008-9292.2020.02.04 |
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| Authors: | ZHANG Xiaoyan SUN Wei SHANG Shiqiang MAO Jianhua FU Junfen SHU Qiang JIANG Kewen |
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| Affiliation: | BioBank of Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310051, China |
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| Abstract: | Coronavirus disease 2019 (COVID-19) is a grade B infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In pace with the spreading of the disease, biosafety risk of the biological specimen preservation in biobanks has been significantly increased and biosafety protection during biological specimen preservation become increasingly important. According to the related national rules and the corresponding guidelines of Chinese Medical Association, this paper introduced the etiology about SARS-CoV-2, epidemiology about COVID-19, and the biosafety protection principles of individuals and biological specimen storage places in the process of personal protection, protection of collection, transport, handling, preservation, detection, post-detection disposal and emergencies of biological specimen. Emphasized to carry out a strict biosafety-risk assessment on biological specimen basing on virus load information, infectivity, and sample type (possible contact transmission, aerosol transmission, and fecal oral transmission). |
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| Keywords: | Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Novel coronavirus pneumonia Biological specimen banks Safety management Preservation biological |
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