OGG1 rs1052133 Polymorphism and Genetic Susceptibility to Chronic Myelogenous Leukaemia |
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| Authors: | Fathelrahman M Hassan |
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| Affiliation: | Department of Clinical laboratory Science, College of Applied Medical Science, Imam Abdulrahman, Bin Faisal University, Saudi Arabia. |
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| Abstract: | Background: In some cancer cells, the OGG1 gene is somatically mutated and highly populated. This study wasconducted to examine whether OGG1 rs1052133 polymorphism is associated with the genetic background of chronicmyelogenous leukaemia (CML) in Sudan. Methods: A total of 332 CML patients and 70 healthy controls were includedin this study. Overall, the genotypes (P=0.0000) and allele (C vs. G, P=0.0007) differed considerably in the frequenciesof OGG1 rs1052133 polymorphism between CML patients and controls. Our study is the first to evaluate the associationof polymorphism with CML risk with OGG1 rs1052133. Results: A statistically significant association was observedbetween the genotype distribution of OGG1 rs1052133 polymorphism and CML (P=0.0000) patients. A similar resultwas also observed in the allele distribution (C vs. G, P=0.0007) compared with healthy controls when comparedOGG1 rs1052133 genotypes with CML stages. Results: Genotype and allele frequencies of OGG1 rs1052133 amongCML patients. A statistically significant association was observed between the genotype distribution of the OGG1rs1052133 polymorphism and CML patients (P=0.0000). A similar result was also observed in the allele distribution(C vs. G, P=0.0007) compared with healthy controls with stages of CML in OGG1 rs1052133 genotypes. Conclusion:The results suggest that single nucleotide polymorphism in the gene involved in the restoration of DNA base excision(OGG1 rs1052133) can play a key role in the risk of appearance of CML. To clarify the role of OGG1 in the geneticbasis of CML, further case control with larger sample sizes and fine-mapping is required. |
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| Keywords: | CML OGG1 rs1052133 Polymorphism Sudanese |
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