Risk of Acute Lymphoblastic Leukemia: Results of a Case-Control Study |
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| Authors: | Hassan Rafieemehr1Fereshteh Calhor2Hossein Esfahani3Somayeh Ghorbani Gholiabad4 |
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| Affiliation: | 1Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran.2Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.3Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.4Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Iran. |
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| Abstract: | Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Differentenvironmental factors might be effective in the occurrence of this malignancy during childhood. The aim of this studywas to find environmental risk factors in childhood ALL in Hamadan, Iran. Methods: This case-control study wasdone in 2015-2018 on 125 children younger than 15 years of age suffering from ALL. Patients were matched with130 controls with respect to age, gender, and residence location. The identification of risk factors for ALL was soughtbased on the comparison of studied variables between case and control individuals. Results: A statistically significantincreased risk for ALL was found with regard to type of delivery (OR: 0.43, 95% CI: 0.20 - 0.92, p˂0.02), childcare(OR: 4.58, 95% CI: 0.95 - 22.20, p˂0.04), birth weight (OR: 1.44, 95% CI: 1.53 - 2.21, p˂0.006), father’s educationlevel (OR: 2.67, 95% CI: 1.10 - 6.45, p˂0.02), and father’s job (OR: 0.2 95% CI: 0.08 - 0.51, p˂0.001). Also observedwere increased odds for ALL regarding male gender, mother’s high education level, mother’s freelance job, and mediumor high family income. No association with ALL incidence was observed for age, gender, breastfeeding, mother’s ageat pregnancy, malignancy in first- or second-degree relatives, or mother’s use of hair dye during pregnancy (p> 0.05).Conclusion: This study showed that father’s education level, father’s job, delivery type, birth weight, and childcarecan play a role in the incidence of childhood ALL. |
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| Keywords: | Acute Lymphoblastic Leukemia children Parents risk factors |
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