| COPD合并细菌感染患者的外周血免疫细胞变化 |
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| 引用本文： | 赵晓丽,唐树荣,王司辰,钱净,任宝军,曾文,胡大春. COPD合并细菌感染患者的外周血免疫细胞变化[J]. 昆明医科大学学报, 2019, 40(3): 49-52 |
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| 作者姓名： | 赵晓丽 唐树荣 王司辰 钱净 任宝军 曾文 胡大春 |
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| 作者单位： | 昆明市第一人民医院昆明医科大学附属甘美医院检验科 |
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| 基金项目： | 基金: 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468 (-098) ]; |
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| 摘 要： | 目的 探讨慢性阻塞性肺疾病 (COPD) 合并感染患者细胞免疫功能状态变化, 为COPD患者免疫调节治疗提供客观依据。方法 选取昆明市第一人民医院2016年1月至2017年3月收治的COPD合并细菌感染患者80例作为观察组, 另选取同期61例单纯COPD患者作为单纯COPD对照组, 60例健康人群作为健康对照组。用流式细胞技术分析3组研究对象外周血免疫细胞水平变化。结果 (1) COPD合并感染组人群外周血NK细胞百分比平均水平为 (19.86±10.67) %, 低于COPD组人群水平 (26.47±10.05) %, 差异有统计学意义 (P <0.01) ;高于健康对照组水平 (16.89±5.07) %, 但差异无统计学意义 (P> 0.05) ; (2) COPD合并细菌感染组、COPD组和健康对照组人群的外周血CD3+细胞 (总T淋巴细胞) 百分比水平分别为 (66.64±11.03) %、 (64.6±11.45) %和 (67.06±5.55) %, 3组间的差异无统计学意义 (P> 0.05) ; (3) COPD合并感染组人群的外周血CD4细胞和CD4/CD8比值分别为 (40.47±10.44) %和1.82 (1.78, 2.57) , 高于健康对照组人群的 (35.01±7.16) %和1.19 (0.96, 1.66) , CD8细胞水平为 (23.6±9.82) %, 低于健康对照组的 (27.50±5.85) %, 差异均有统计学意义 (P <0.01) ;但与COPD组的水平 (39.89±9.92) %、 2.02 (1.44, 2.83) 和 (21.12±7.64) %差异无统计学意义 (P> 0.05) 。结论 COPD患者辅助性免疫细胞水平升高, 但特异杀伤性免疫细胞水平降低, 在此基础上, 非特异性杀伤性免疫细胞水平升高有助于抵御感染, COPD患者的免疫调节治疗应注重提升杀伤性免疫细胞水平。
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| 关 键 词： | 慢性阻塞性肺疾病 感染 细胞免疫 |
| 收稿时间： | 2018-11-12 |
Changes of Cellular Immune Function in Chronic Obstructive Pulmonary Disease Patients with Infection |
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| Abstract: | Objective To explore the changes of cellular immune function in chronic obstructive pulmonary disease patients with infection, and to provide a theoretical basis for COPD patients. Methods Totally 80 patients with COPD complicating infection treated in our hospital from January 2016 to April 2017 were selected as the observation group, contemporaneous 64 patients with simple COPD were selected as the COPD group and 60 healthy people as the control group. The indexes of cellular immunity functions were analyzed in 3 groups. Results (1) In COPD infection group, the average percentage of peripheral blood NK was 19.86 + 10.67, and lower than the COPD group (26.47±10.05) , the difference was statistically significant (P < 0.01) , higher than that of the control group (16.89±5.07) , but the difference was not statistically significant (P > 0.05) . (2) CD3+ cells in peripheral blood of COPD patients with bacterial infection group, COPD group and healthy control group (total T lymphocyte percentage) were (66.64±11.03) , (64.6±11.45) and (67.06±5.55) , there was no significant difference between the three groups (P > 0.05) . (3) In COPD infection group, the peripheral blood CD4 cells and CD4/CD8 ratio were (40.47±10.44) and 1.82 (1.78, 2.57) , higher than the healthy control group[35.01 +7.16 and 1.19 (0.96, 1.66) ], the level of CD8 cells was (23.6±9.82) , lower than the healthy control group (27.50±5.85) , the differences were statistically significant (P < 0.01) ;and COPD group level[ (39.89±9.92) , 2.02 (1.44, 2.83) ] and (21.12±7.64) , there were no statistically significant difference. Conclusions In patients with COPD, the adjuvant immune cell levels are increased but the specific killing immune cells are decreased, on this basis, increased levels of nonspecific killing immune cells help fight infection, immune regulation therapy for COPD patients should focus on improving the level of destruction of immune cells. |
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