| Abstract: | Background: Different studies have been conducted to estimate the survival rate of colorectal cancer in Iran butthere is no overall estimate of the survival rate. The aim of this study was to calculate the pooled 1, 3, and 5-year survivalrate of the patients with colorectal cancer in Iran. Methods: To retrieve relevant studies, we conducted a systematicsearch in Iranian databases, including Iran Medex, Magiran, SID, and international databases such as Medlin/PubMed,Scopus, and Google scholar using “Colorectal Neoplasms” and “Survival Rate” as keywords up to December 1st, 2017.We used random effect model to estimate pooled 1, 3, and 5-year survival rates of the patients with colorectal cancerin Iran. To assess the heterogeneity, we used Chi-squared test at the 5 % significance level (p <0.05) and I2 Index. Weused meta-regression and subgroup analysis to find a potential source of heterogeneity. Results: After a systematicsearch, 196 articles were found, of the 38 studies met the eligibility criteria and are included in our meta-analysis. Thepooled 1, 3, and 5-year survival rates in patient with colorectal cancer were 0.84 (95% CI: 0.81-0.87), 0.64 (95%CI:0.59-0.70), and 0.54 (95%CI: 0.49-0.58) respectively. The 5-year survival rate in the subgroup of women was 0.5(0.44-0.56) and in male subgroup was 0.44 (0.40-0.48). In a subgroup of the tumor site, the 5-year survival rate in coloncancer was 0.6 (0.49-0.75) and rectum cancer was 0.54 (0.36-0.69). In multivariable models, there was a significantassociation between years of study and 5-year survival rate as a source of heterogeneity (β = 18.9, P=0.01). Conclusion:According to the results of this study, women had a better survival rate than men, and according to the tumor site, the5-year survival rate in colon cancer was better than the rectum cancer. |
