Pulmonary anthracosis mimicking lung metastases in pediatric rhabdomyosarcoma |
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| Authors: | Gabrielle Karpinsky Malgorzata Anna Krawczyk Aleksandra Fatyga Ewa Izycka‐Swieszewska Miroslawa Dubaniewicz‐Wybieralska Dagmara Szmyd Monika Luboch‐Furmanczyk Ewa Bien |
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| Affiliation: | 1. Children's Hospital of Michigan, Detroit, Michigan, USA;2. Department of Pediatrics, Hematology and Oncology, University Clinic Center, Gdansk, Poland;3. Department of Pathology and Neuropathology, Medical University of Gdansk, Gdansk, Poland;4. Department of Radiology, Medical University of Gdansk, Gdansk, Poland;5. Blackpool Victoria Hospital, Blackpool, Lancashire, UK;6. Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk, Poland;7. Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland |
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| Abstract: | Although childhood rhabdomyosarcoma typically metastasizes to lungs, various processes may mimic metastatic etiology. Described herein is the case of an 8½‐year‐old boy with orbital embryonal rhabdomyosarcoma (RME) in whom three small foci were detected within both lungs on computed tomography. The lesion number and size, however, did not fulfil the Cooperative Weichteilsarkom Study Group 2006 protocol criteria for lung metastasis. Chemotherapy for localized RME produced primary tumor regression and vanishing of the left lung lesion. Two lesions in the right lung remained unchanged. On thoracoscopy multiple minute nodules disseminated in both lungs were detected. Histopathology excluded RME spread but indicated anthracosis in the lung parenchyma and intrapulmonary lymph nodes. Heavy smoking by parents and previous home furnace combustion appeared to be predisposing factors. Uncommon non‐malignant intrapulmonary diseases, including anthracosis, should be considered when staging pediatric cancer. |
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| Keywords: | benign lung lesion child embryonal rhabdomyosarcoma lung metastasis pulmonary anthracosis |
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