Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy |
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| Authors: | Lars H. Markvardsen MD PhD Kristian Overgaard MSc PhD Karen Heje MD Søren H. Sindrup MD DMSc Ingelise Christiansen MD PhD John Vissing MD DMSc Henning Andersen MD DMSc |
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| Affiliation: | 1. Department of Neurology, Aarhus University Hospital, Aarhus C, Aarhus, Denmark;2. Section for Sport Science, Department of Public Health, Aarhus University, Aarhus, Denmark;3. Department of Neurology, Copenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;4. Department of Neurology, Odense University Hospital, Odense, Denmark |
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| Abstract: | Introduction: We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run‐in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension. Primary outcomes were maximal oxygen consumption velocity (VO2‐max) and maximal combined isokinetic muscle strength (cIKS) of knee and elbow flexion/extension. Results: VO2‐max and muscle strength were unchanged during run‐in (?4.9% ± 10.3%, P = 0.80 and ?3.7% ± 10.1%, P = 0.17, respectively). Aerobic exercise increased VO2‐max by 11.0% ± 14.7% (P = 0.02). Resistance exercise resulted in an increase of 13.8% ± 16.0% (P = 0.0004) in cIKS. Discussion: Aerobic exercise training and resistance exercise training improve fitness and strength in CIDP patients. Muscle Nerve 57 : 70–76, 2018 |
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| Keywords: | aerobic training chronic inflammatory demyelinating polyneuropathy quality of life resistance training subcutaneous immunoglobulin |
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