| 乳腺癌骨转移研究的新进展及展望——从机制到临床 |
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| 引用本文： | 王家辉,蒋林兰,沈赞. 乳腺癌骨转移研究的新进展及展望——从机制到临床[J]. 中国癌症杂志, 2022, 32(2): 172-176. DOI: 10.19401/j.cnki.1007-3639.2022.02.009 |
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| 作者姓名： | 王家辉 蒋林兰 沈赞 |
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| 作者单位： | 上海交通大学附属第六人民医院肿瘤内科,上海 200233 |
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| 基金项目： | 国家自然科学基金(81972521)。 |
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| 摘 要： | 乳腺癌骨转移是晚期乳腺癌患者严重的并发症之一.骨转移后出现的严重骨痛、病理性骨折等并发症,严重影响患者的生活质量并缩短其生存期.近年来,随着对乳腺癌骨转移机制以及肿瘤细胞与骨微环境之间相关调控网络的认知不断深入,许多新药的开发和应用使乳腺癌骨转移的治疗取得重大进展.现就乳腺癌骨转移机制及目前治疗研究进展进行综述.
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| 关 键 词： | 乳腺癌 骨转移 机制 治疗 |
| 收稿时间： | 2021-05-30 |
New progress and prospect of breast cancer bone metastasis research from mechanism to clinic |
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| WANG Jiahui,JIANG Linlan,SHEN Zan. New progress and prospect of breast cancer bone metastasis research from mechanism to clinic[J]. China Oncology, 2022, 32(2): 172-176. DOI: 10.19401/j.cnki.1007-3639.2022.02.009 |
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| Authors: | WANG Jiahui JIANG Linlan SHEN Zan |
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| Affiliation: | Department of Oncology, the 6th People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China |
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| Abstract: | Bone metastasis is one of the most serious complications in advanced breast cancer patients.Severe osteodynia,pathological fracture and other complications in bone metastasis of breast cancer can seriously affect the quality of life and shorten life span.In recent years,with the further understanding of the mechanism of bone metastases and the cross-talk between tumor cells and bone microenvironment,development and application of many new effective drugs have made significant progress in the treatment of bone metastasis of breast cancer.This article reviewed the mechanism of bone metastasis of breast cancer and current treatment advances. |
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| Keywords: | Breast cancer Bone metastasis Mechanism Treatment |
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