| 不可切除肝门胆管癌的光动力学治疗现状 |
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| 引用本文： | 李志原,李小祺,崔培元. 不可切除肝门胆管癌的光动力学治疗现状[J]. 中国肿瘤临床, 2016, 43(16): 735-738. DOI: 10.3969/j.issn.1000-8179.2016.16.517 |
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| 作者姓名： | 李志原 李小祺 崔培元 |
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| 作者单位： | 作者单位:蚌埠医学院第一附属医院肝胆外科(安徽省蚌埠市233000) |
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| 摘 要： | 肝门胆管癌是一种少见的起源于胆管上皮细胞的恶性肿瘤。目前肝门胆管癌的主要治疗方式为:手术切除、放疗、化疗、光动力疗法（photodynamic therapy ，PDT ）。 根治性手术切除是目前可能治愈肝门胆管癌并最大限度延长生存期的唯一方法，然而超过一半的患者在确诊时已属肿瘤晚期而丧失手术机会。放疗和化疗能否延长患者生存期仍缺少可靠大数据研究的支持。多数无法行手术治疗的患者为解除胆道梗阻只能行胆道支架置入术，但无法延长生存期。PDT 是新兴的一种可以治疗多种恶性肿瘤的方法，已有多项临床研究表明其具有局部消融肿瘤的能力。因此，PDT 在治疗不可切除肝门胆管癌有着广阔的应用前景。
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| 关 键 词： | 肝门胆管癌? 光动力疗法? 光敏剂 支架植入术 生存期 |
| 收稿时间： | 2016-05-04 |
Current status of photodynamic therapy for unresectable hilar cholangiocarcinoma |
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| Affiliation: | Department of Hepatobiliary Surgery, the First Affiliated Hospital, Bengbu Medical College, Bengbu 233000, China |
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| Abstract: | Hilar cholangiocarcinoma is a rare biliary malignant tumor derived from the biliary epithelial cell. The primary current treat-ments for hilar cholangiocarcinoma include surgery and chemotherapy, as well as radiation and photodynamic therapies (PDT). A com-plete resection with negative margins is the only treatment with the potential for cure and the only way to maximize survival. Howev-er, over half of the patients in the advanced stage of hilar cholangiocarcinoma lost the chance for surgery. Radiotherapy and chemo-therapy can prolong patient survival;however, these lack reliable data. Most patients who cannot be treated surgically undergo biliary stenting to relieve the biliary obstruction. The PDT is a new method to treat various malignant tumors. Several clinical studies have shown its local tumor ablation capability. Thus, PDT has broad application prospects in the treatment of unresectable hilar cholangio-carcinoma. |
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| Keywords: | hilar cholangiocarcinoma photodynamic therapy photosensitizer endoprostheses survival |
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