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| HBeAg阴性和阳性慢性乙型肝炎患者血清HBV DNA水平与肝组织炎症的关系 | |
| 引用本文： | 李仕周,蒋永芳. HBeAg阴性和阳性慢性乙型肝炎患者血清HBV DNA水平与肝组织炎症的关系[J]. 世界华人消化杂志, 2006, 14(33): 3241-3244 |
| 作者姓名： | 李仕周 蒋永芳 |
| 作者单位： | 1. 湖南省郴州市第一人民医院消化内科,湖南省郴州市,423000 2. 中南大学湘雅二医院肝病研究中心,湖南省长沙市,410011 |
| 摘 要： | 目的:探讨HBeAg阴性和HBeAg阳性慢性乙型肝炎(CHB)HBVDNA水平和肝组织炎症损害的关系.方法:采用荧光定量聚合酶链反应分别对331例CHB(101例HBeAg阴性和230例HBeAg阳性)患者进行血清HBVDNA定量检测和肝组织活检病理炎症分级,对比分析结果.结果:331例CHB患者血清HBVDNA水平与肝组织炎症活动度及肝纤维化程度之间无明显相关性;101例HBeAg阴性CHB患者中31例(31%)血清HBVDNA>108copies/L,随着G1-G4肝组织炎症损害级别的增高其所占例数也相应增高.HBVDNA水平与肝组织炎症病理分级的相关性有显著意义(r=0.271,P<0.005);在230例HBeAg阳性的患者中,血清HBVDNA水平与肝组织炎症呈明显的负相关(r=-0.659,P<0.001).结论:血清HBVDNA水平可作为判断HBeAg阴性CHB患者肝组织炎症损害程度的指标,在HBeAg阳性的患者中,血清HBVDNA水平与肝组织炎症呈负相关. |
| 关 键 词： | 乙型肝炎 HBV DNA 肝组织炎症 |
| 收稿时间： | 2006-09-11 |
| 修稿时间： | 2006-09-11 |
Relationship between liver pathologic histology and levels of serum hepatitis B virus DNA in patients with HbeAg-positive and-negative chronic hepatitis B |
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| Shi-Zhou Li,Yong-Fang Jiang. Relationship between liver pathologic histology and levels of serum hepatitis B virus DNA in patients with HbeAg-positive and-negative chronic hepatitis B[J]. World Chinese Journal of Digestology, 2006, 14(33): 3241-3244 | |
| Authors: | Shi-Zhou Li Yong-Fang Jiang |
| Abstract: | AIM: To investigate the relationship betweenserum hepatitis B virus (HBV) DNA levels andthe inflammatory degrees of liver tissues inpatients with HBeAg-positive and -negativechronic hepatitis B.METHODS: HBV DNA level was assayed byfluorescent quantitative polymerase chain reac-tion (FQ-PCR) in 331 patients (230 HBeAg posi-tive and 101 HBeAg negative). Liver biopsy wasperformed and the grading and staging of livertissues were routinely obtained.RESULTS: There was not obvious correlationbetween serum HBV DNA level and the grad-ing and staging of liver tissues in 331 patientswith chronic hepatitis B. Of the 101 patients withnegative HBeAg, 31 cases were with more than108 copies/L HBV DNA, and there was signifi-cant correlation between HBV DNA level and the grading of tissues (r = 0.271, P < 0.005). A significant inverse correlation was demonstrated between HBV DNA level and hepatitis activ-ity in the 230 patients with positive HBeAg (r = -0.659, P < 0.001).CONCLUSION: The serum level of HBV DNA can help to assess the degrees of hepatitis activ-ity in patients with negative HBeAg. In HBeAg-positive patients, the serum level of HBV DNA is negatively correlate with hepatic activity index. |
| Keywords: | Chronic hepatitis B Liver pathologic histology HBV DNA |
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