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| 上海市虹口区妇女高危型人乳头瘤病毒感染及宫颈癌前病变情况分析 | |
| 引用本文： | 张丽华, 张敏, 胡争光, 龚向真, 徐爱娣. 上海市虹口区妇女高危型人乳头瘤病毒感染及宫颈癌前病变情况分析[J]. 上海预防医学, 2010, 22(5): 229-231. |
| 作者姓名： | 张丽华 张敏 胡争光 龚向真 徐爱娣 |
| 作者单位： | 1.1. 复旦大学附属肿瘤医院, 上海 200032 |
| 摘 要： | [目的] 了解上海市虹口区普查妇女中高危型人乳头瘤病毒(HPV)的感染情况,并探讨其在宫颈癌前病变中的作用。[方法] 对318例普查妇女行高危型HPV-DNA检测及病理检测。[结果] 病理检查阴性者HPV感染率为10.8%(21/195),低度子宫颈病变者HPV感染率为25.0%(4/16),高度子宫颈病变者HPV感染率为81.8%(9/11)。HPV诊断宫颈癌前病变的灵敏度为48.1%,特异度为89.2%,阳性预测值为38.2%,阴性预测值为92.6%。[结论] HPV感染是宫颈癌及癌前病变的高危因素。HPV-DNA检测具有较高的阴性预测值,在宫颈癌筛查中具有重要作用。 |
| 关 键 词： | 人乳头瘤病毒 宫颈癌前病变 宫颈癌 病因学 |
| 收稿时间： | 2009-12-15 |
Clinical research on infection with high-risk types of human papillomavirus and cervical precancerous lesion in women of Hongkou District in Shanghai |
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| ZHANG Li-hua, ZHANG Min, HU Zheng-guang, GONG Xiang-zhen, XU Ai-di. Clinical research on infection with high-risk types of human papillomavirus and cervical precancerous lesion in women of Hongkou District in Shanghai[J]. Shanghai Journal of Preventive Medicine, 2010, 22(5): 229-231. | |
| Authors: | ZHANG Li-hua ZHANG Min HU Zheng-guang GONG Xiang-zhen XU Ai-di |
| Affiliation: | 1.1. Cancer Hospital, Fudan University, Shanghai 200032, China |
| Abstract: | [Objective] To investigate the morbidity of cervical high-risk types of human papillomavirus(HPV) infection in women screened in Hongkou District of Shanghai and explore its role in cervical precursor lesion. [Methods] The cervical specimens from a series of 318 women were investigated to detect high-risk HPV-DNA(HC-II).Pathological result was golden standard. [Results] The sensitivity,specificity,positive predictive value,and negative predictive values of HPV-DNA test were 48.1%,89.2%,38.2% and 92.5% respe... |
| Keywords: | HPV Cervical precancerous lesion Cervical cancer Etiology |
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