| 开搏通逆转高血压性心肌肥大过程中心肌超微结构的变化 |
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| 引用本文： | 佟长青,王义和,齐莉,李海英,刘子泉. 开搏通逆转高血压性心肌肥大过程中心肌超微结构的变化[J]. 心脏杂志, 2003, 15(6): 504-507. DOI: 10.13191/j.chj.2003.06.26.tongzhq.008 |
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| 作者姓名： | 佟长青 王义和 齐莉 李海英 刘子泉 |
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| 作者单位： | 天津武警医学院生理学教研室,天津,300162 |
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| 摘 要： | 目的 :探讨开搏通逆转高血压性心肌肥大对心脏超微结构的作用。方法 :用多道生物信号系统记录血压和心率 ,用电子显微镜观察心肌超微结构。结果 :第 4、8、12周 ,高血压组的 SBP,DBP,MAP比对照组高 ,第 16周差别不明显 ,假手术组和对照组的差别无统计学意义 ;在第 4、8、12周 ,T管和肌浆网扩张 ,第 16周大部 T管和肌浆网恢复正常 ;在第 4周 ,粗、细肌丝溶解 ,第 16周 ,大部分粗、细肌丝清晰 ,排列正常。结论 :开搏通能降低腹主动脉缩窄大鼠的血压和逆转心肌肥大 ;在第 4周 ,高血压组肌纤维和肌管出现病理变化 ,在第 16周大多数粗、细肌丝和 T管、肌浆网恢复正常
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| 关 键 词： | 高血压性心肌肥大 开搏通 超微结构 |
| 文章编号： | 1009-7236(2003)06-0504-04 |
| 修稿时间： | 2002-12-25 |
The changes in ultramicro-structure during regression of hypertensive cardiac hypertrophy by Captopril in rats |
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| TONG Chang-qing,WANG Yi-he,QI Li,LI Hai-ying,LIU Zi-quan. The changes in ultramicro-structure during regression of hypertensive cardiac hypertrophy by Captopril in rats[J]. Chinese Heart Journal, 2003, 15(6): 504-507. DOI: 10.13191/j.chj.2003.06.26.tongzhq.008 |
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| Authors: | TONG Chang-qing WANG Yi-he QI Li LI Hai-ying LIU Zi-quan |
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| Abstract: | AIM: To investigate the action of Captopril on ultramicr o -structure in regression of left ventricular hypertrophy induced by hypertensio n in rats. METHODS: Blood pressure and heart rate were recorded with polygraph cha nnel system,an d the ultramicro structure of myocardium was observed by transmission electrom icroscopy. RESULTS: SBP,DBP,MAP in hypertension group (H) at 4th,8th,12th weeks were higher than those of the control group(C);at 16th week difference among groups was not remarkable,and no statistics significance was found between the pseudo o peration group(P) and the control group. At 4th,8th,12th weeks enlarging of T tubl and sarc oplasmic reticulum(SR) was found,at 16th week T tubl, SR for the most part were normal. At 4 th week dissolving of thick and thin filaments in myofibril s was obsered. At 16th week thick and thin filaments in myofibrils were clear,ra n king and their was normal. CONCLUSION: Captopril reduced bl ood pressure and reversed cardiac hypertrophy of abdomonal aortic banding rats. At 4th week pathological changes in myofibrils were seen,in the hypertension group, at 16th week thick a nd thin filaments, T tuble and SR were normal for the great part. |
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| Keywords: | hypertentive cardiac hypertrophy Captopril ultram icro-structure |
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