| 中国肝细胞癌和肝内胆管细胞癌临床诊疗情况比较研究 |
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| 引用本文： | 安澜,冉显会,郑荣寿,陈茹,王少明,孙可欣,雷林,曾红梅,魏文强,张敏,张思维. 中国肝细胞癌和肝内胆管细胞癌临床诊疗情况比较研究[J]. 中国癌症防治杂志, 2021, 13(2): 126-132. DOI: 10.3969/j.issn.1674-5671.2021.02.03 |
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| 作者姓名： | 安澜 冉显会 郑荣寿 陈茹 王少明 孙可欣 雷林 曾红梅 魏文强 张敏 张思维 |
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| 作者单位： | 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室；深圳市慢性病防治中心肿瘤防控科湖北省肿瘤医院肿瘤防治办公室 |
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| 基金项目： | 国家重点研发计划项目(2016YFC1302502);中国医学科学院医学与健康科技创新工程(2019-I2M-2-004;2018-I2M-3-003);深圳市医疗卫生三名工程(SZSM 201911015)。 |
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| 摘 要： | 目的 分析中国多中心肝细胞癌(hepatocellular carcinoma,HCC)和肝内胆管细胞癌(intrahepatic cholangio-carcinoma,ICC)的临床诊疗情况,为制定肝癌防治措施提供依据.方法 研究对象来源于2016—2017年全国12个省市33家医院首次确诊/治疗的新发HCC和IC...
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| 关 键 词： | 肝细胞癌 肝内胆管细胞癌 临床诊疗 病理类型 分期 |
A comparative study on clinical diagnosis and treatment of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in China |
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| AN Lan,RAN Xianhui,ZHENG Rongshou,CHEN Ru,WANG Shaoming,SUN Kexin,LEI Lin,ZENG Hongmei,WEI Wenqiang,ZHANG Min,ZHANG Siwei. A comparative study on clinical diagnosis and treatment of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in China[J]. Journal of Chinese Medical Abstracts·Oncology, 2021, 13(2): 126-132. DOI: 10.3969/j.issn.1674-5671.2021.02.03 |
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| Authors: | AN Lan RAN Xianhui ZHENG Rongshou CHEN Ru WANG Shaoming SUN Kexin LEI Lin ZENG Hongmei WEI Wenqiang ZHANG Min ZHANG Siwei |
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| Affiliation: | (National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;Shenzhen Center for Chronic Disease Control,Shenzhen 518020,China;Hubei Cancer Hospital,Wuhan 430079,China) |
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| Abstract: | ObjectiveTo analyze the clinical diagnosis and treatment of hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)from various clinical centers in China,and to provide the evidence for prevention and treatment measures.MethodsThe studied objects were gathered from new HCC or ICC cases diagnosed/treated for the first time in 33 hospitals in 12 provinces and cities from 2016 to 2017.The basic information,risk factors,clinical diagnosis and treatment information were collected,and the distribution characteristics of HCC and ICC were compared.ResultsA total of 3,258 liver cancer patients HCC were collected,including 2,671 males(81.98%)and 587 females(18.02%),with 2,928 HCC patients(89.87%)and 330 ICC patients(10.13%).In both HCC and ICC patients,the proportion of males were higher than that of females,and the urban patients were more than the rural patients.The mean onset ages of HCC and ICC were(56.44±11.65)and(61.20±10.92)years,respectively.In HCC patients,the proportions of patients with smoking history(43.64%vs 33.44%,P=0.0004),with alcohol drinking history(31.14%vs 22.15%,P=0.0008),with a history of liver related disease(67.74%vs 34.16%,P<0.0001)and hepatitis B virus carriers(79.37%vs 64.55%,P=0.0002)were all higher than those in ICC patients.The proportions of HCC patients at early stage(Ⅰ-Ⅱstage)and advanced stage(Ⅲ-Ⅳstage)were 44.10%and 55.90%,respectively,while those of ICC patients were 17.01%and 82.99%,respectively,with statistically significant differences(P<0.0001).The main treatment options for HCC and ICC patients were surgery,interventional therapy and chemotherapy,the ratios of surgery were 60.64%and 45.31%,respectively;the ratios of interventional treatment were 23.86%and 21.50%,respectively;the ratios of chemotherapy were 22.13%and 24.77%,respectively.Conclusions The distribution characteristics of the HCC and ICC patients in China are different,and the proportion of advanced stage at the first diagnosis is high,and the main treatment options are surgery,interventional treatment and chemotherapy.HCC is the most common type of liver cancer,the prevention and control of liver cancer should be focused on male,middle-aged and elderly people. |
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| Keywords: | Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Diagnosis/Treatment Histological subtype Stage |
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