Oncogenic human papillomavirus DNA loads in human immunodeficiency virus-positive women with high-grade cervical lesions are strongly elevated |
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| Authors: | Weissenborn S J Funke A M Hellmich M Mallmann P Fuchs P G Pfister H J Wieland U |
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| Affiliation: | Institute of Virology, University of Cologne, 50935 Cologne, Germany. soenke.weissenborn@medizin.uni-koeln.de |
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| Abstract: | Human papillomavirus (HPV) DNA loads of six oncogenic HPV types were measured by real-time PCR in cervical scrapes of human immunodeficiency virus (HIV)-infected and uninfected women. In both groups, HPV loads increased with the grade of cervical disease. HIV infection did not affect HPV loads in low-grade lesions but was associated with significantly higher HPV loads in severe dysplasia; highest loads were found in advanced HIV disease. Our data reflect the aggressive course of HPV infection in HIV-positive women. |
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