| 蛋白磷酸酶PHLPP对Akt通路的抑制作用 |
| |
| 引用本文： | 吴伟强,殷玥,马恒. 蛋白磷酸酶PHLPP对Akt通路的抑制作用[J]. 心脏杂志, 2012, 24(2): 263-266 |
| |
| 作者姓名： | 吴伟强 殷玥 马恒 |
| |
| 作者单位： | (第四军医大学:1.学员17队，2.生理学教研室，陕西 西安 710032) |
| |
| 摘 要： | 近年发现的蛋白磷酸酶PHLPP日益得到重视。PHLPP能够特异性地使蛋白激酶B（Akt）发生去磷酸化并抑制其活性，进而参与细胞生理功能的调控。PHLPP与肿瘤、糖尿病及心肌缺血/再灌注损伤等疾病的发生发展也有密切关系。
|
| 关 键 词： | 蛋白激酶B PHLPP 肿瘤 糖尿病 缺血/再灌注 |
| 收稿时间： | 2011-06-27 |
Suppression of Akt pathway by protein phosphatase PHLPP |
| |
| WU Wei-qiang,YIN Yue,MA Heng. Suppression of Akt pathway by protein phosphatase PHLPP[J]. Chinese Heart Journal, 2012, 24(2): 263-266 |
| |
| Authors: | WU Wei-qiang YIN Yue MA Heng |
| |
| Affiliation: | 1.17th Cadet Battalion,2.Department of Physiology,Fourth Military Medical University,Xi’an 710032,Shaanxi,China) |
| |
| Abstract: | As a novel protein phosphatase,PHLPP specifically induces dephosphorylation of protein kinase B(Akt) that inhibits Akt activity.The role of PHLPP in cell physiological regulation has led to increasing attention to this process.The close relationship with the onset of tumors,diabetes and myocardial ischemia/reperfusion injury all highlight the important biological function of PHLPP. |
| |
| Keywords: | Akt PHLPP tumor diabetes ischemia/reperfusion |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《心脏杂志》浏览原始摘要信息 |
|
点击此处可从《心脏杂志》下载免费的PDF全文 |
