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| 胰岛素改善严重烫伤大鼠心脏功能和生存率的实验研究 | |
| 引用本文： | 蔡晓庆,曹兵,张利华,刘文冲,张海锋,李嘉,高峰. 胰岛素改善严重烫伤大鼠心脏功能和生存率的实验研究[J]. 心脏杂志, 2012, 24(2): 150-153 |
| 作者姓名： | 蔡晓庆 曹兵 张利华 刘文冲 张海锋 李嘉 高峰 |
| 作者单位： | (第四军医大学:1.生理学教研室，2.口腔医学系，陕西 西安 710032，3.唐都医院心血管内科，陕西 西安 710038) |
| 基金项目： | 国家自然科学基金项目资助(30800447),国家自然科学基金重点项目资助(81030005) |
| 摘 要： | 目的:探讨大鼠烫伤后早期胰岛素治疗对心脏功能和死亡率的影响。方法:将60只成年SD大鼠随机分为对照组(37℃温水处理)、烫伤组（95℃热水处理）和胰岛素治疗组（皮下注射胰岛素2.5 U/kg），每组20只（n=20），于大鼠烫伤后30 min、1 h和3 h，观察各组大鼠血糖的变化，测定烫伤后3 h心脏的功能，于大鼠烫伤后8 h，记录各组大鼠的内生存状况。结果:与对照组相比，烫伤组的血糖显著上升(P<0.01)，心脏功能明显下降(P<0.01)。早期胰岛素治疗可降低烫伤后大鼠的血糖(P<0.01)，改善大鼠心脏的功能(P<0.05)。烫伤组大鼠8 h内累积死亡率为40%，而胰岛素治疗组未出现大鼠死亡。结论:重度烫伤后，早期胰岛素治疗可改善大鼠心脏的功能，提高大鼠的生存率。 |
| 关 键 词： | 烫伤 胰岛素 心脏功能 死亡率 大鼠 |
| 收稿时间： | 2011-08-22 |
Insulin alleviates cardiac dysfunction and improves survival rate in rats after severe scald injury |
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| CAI Xiao-qing,CAO Bing,ZHANG Li-hua,LIU Wen-chong,ZHANG Hai-feng,LI Jia,GAO Feng. Insulin alleviates cardiac dysfunction and improves survival rate in rats after severe scald injury[J]. Chinese Heart Journal, 2012, 24(2): 150-153 | |
| Authors: | CAI Xiao-qing CAO Bing ZHANG Li-hua LIU Wen-chong ZHANG Hai-feng LI Jia GAO Feng |
| Affiliation: | 1(1.Department of Physiology,2.Department of Stomatology,3.Department of Cardiology,Tangdu Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi,China) |
| Abstract: | AIM: To investigate the effects of early insulin treatment on cardiac function and survival rate in rats after severe scald injury.METHODS: Sixty male Sprague Dawley(SD) rats were randomized into sham-operated group(in 37℃ water),scald injury group(immersing the back of rats for 15 sec and abdomen for 5 sec in 95℃ water) and insulin treatment group(s.c.injection,2.5 U/kg).Blood glucose was determined at 0 min,30 min,1 h and 3 h post-scald,and cardiac function was observed at 3-h post-scald.The survival status of each rat was recorded 8 h post-scald.RESULTS: Compared with those in the control group,blood glucose soared and cardiac function were impaired in scald injury group at 3 h post-scald(n=10,P<0.01).Early insulin treatment significantly decreased blood glucose(n=10,P<0.01).Meanwhile,cardiac dysfunction was alleviated by insulin treatment(n=10,P<0.05).After early insulin treatment,post-scald survival rate was significantly improved.CONCLUSION: Early insulin treatment alleviates cardiac dysfunction and improves survival rate in rats after severe scald injury. |
| Keywords: | scald insulin stress hyperglycemia cardiac function mortality |
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