| 干预慢性应激在癌症治疗中的作用 |
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| 引用本文： | 李悦,康欣梅. 干预慢性应激在癌症治疗中的作用[J]. 中国肿瘤临床, 2022, 49(7): 372-376. DOI: 10.12354/j.issn.1000-8179.2022.20211505 |
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| 作者姓名： | 李悦 康欣梅 |
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| 作者单位： | 厦门大学附属翔安医院肿瘤科（福建省厦门市361101） |
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| 基金项目： | 福建省自然科学基金项目（编号：2019J01012）; |
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| 摘 要： | 随着临床诊疗向“生物-心理-社会”医学模式转变,癌症患者心理状态愈发受到医务工作者的关注。机体受到内外环境刺激后,为维持内部稳态产生的一系列适应性反应称为应激。癌症患者因对死亡的恐惧、医疗经济负担、癌症造成的疼痛而面临巨大心理压力,上述均为主要的应激原。长期心理压力造成的慢性应激会引起机体内环境稳态失调和神经内分泌功能紊乱,其与肿瘤发生发展、患者生存质量下降及生存期缩短均密切相关。本文将对社会心理压力导致的慢性应激影响肿瘤进展的机制,以及干预慢性应激相关过程对癌症治疗的影响进行综述。
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| 关 键 词： | 慢性应激 心理压力 癌症 干预措施 |
| 收稿时间： | 2021-09-30 |
Effects of chronic stress intervention in cancer treatment |
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| Affiliation: | Department of Medical Oncology, Xiang 'an Hospital of Xiamen University, Xiamen 361101, China |
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| Abstract: | With clinical diagnosis and treatment shifting to the bio-psycho-social model, the psychological state of cancer patients isincreasingly worthy of medical workers' attention. Stress is a series of adaptive responses produced to maintain internal homeostasis when internal and external events impact the body. Many cancer patients endure severe psychological stress because of fear of death, the financial burden of cancer treatment, and the severe pain caused by cancer. Some epidemiological and psychological studies have shown that chronic stress, caused by long-term psychological pressure, contributes to the disruption of homeostasis and neuroendocrine function. These changes relate closely to cancer development, deteriorated quality of life, and shortened survival. This review summarizes the mechanisms of chronic stress induced by social-psychological pressure on tumor progression and the effects of interventions to manage the stress of cancer treatment. |
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