Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus |
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| Authors: | Roilides Emmanuel Lyman Caron A Filioti Joanna Akpogheneta Onome Sein Tin Lamaignere Cristina Gil Petraitiene Ruta Walsh Thomas J |
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| Affiliation: | 3rd Department of Pediatrics, University of Thessaloniki, Hippokration Hospital, Thessaloniki GR-54642, Greece. |
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| Abstract: | Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus. |
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