rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. |
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| Authors: | R Patarca G J Freeman J Schwartz R P Singh Q T Kong E Murphy Y Anderson F Y Sheng P Singh K A Johnson et al. |
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| Affiliation: | Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA. |
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| Abstract: | The Rpt-1 (for regulatory protein, T-lymphocyte, 1) gene, selectively expressed by resting but not by activated CD4+ inducer T cells, encodes an intracellular protein (rpt-1, Mr 41,000) that down-regulates gene expression directed by the promoter region of the gene encoding interleukin 2 receptor alpha chain and by the long terminal repeat of human immunodeficiency virus type 1. The data reported here suggest that rpt-1 levels may be inversely correlated with activation of CD4+ T cells and human immunodeficiency virus replication leading to clinical symptoms of the acquired immunodeficiency syndrome. |
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