Laboratory Evaluation of BL-S786, a Cephalosporin with Broad-Spectrum Antibacterial Activity |
| |
| Authors: | F. Leitner M. Misiek T. A. Pursiano R. E. Buck D. R. Chisholm R. G. DeRegis Y. H. Tsai K. E. Price |
| |
| Affiliation: | 1.Department of Microbiological Research, Bristol Laboratories, Syracuse, New York 13201 |
| |
| Abstract: | Biological and physicochemical properties of BL-S786 were compared with those of cephalothin, cephaloridine, and cefazolin. With few exceptions, BL-S786 was more active than the reference compounds against major gram-negative pathogenic species and its antibacterial spectrum was broader than that of cephalosporins currently available for clinical use. Although BL-S786 was generally less active than the control cephalosporins against gram-positive pathogens, it inhibited their growth at concentrations that should readily be achieved in humans after standard parenteral dosage. Streptococcus faecalis, a species relatively unsusceptible to cephalosporins in general, was an exception. BL-S786 was an effective bactericidal agent for strains of various gram-negative organisms. After intramuscular administration to mice, BL-S786 achieved high concentrations in blood, and its biological half-life was longer than that of the other three cephalosporins. |
| |
| Keywords: | |
|
|
