| ABO血型与HBV相关性肝细胞癌患者肝切除术后预后的关联研究 |
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| 引用本文： | 梁秀妹,蒋燕霁,周泽文,丘嘉琳,龚文锋,马良,向邦德,唐卫中,余红平,周子寒. ABO血型与HBV相关性肝细胞癌患者肝切除术后预后的关联研究[J]. 中国癌症防治杂志, 2021, 13(3): 282-287. DOI: 10.3969/j.issn.1674-5671.2021.03.11 |
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| 作者姓名： | 梁秀妹 蒋燕霁 周泽文 丘嘉琳 龚文锋 马良 向邦德 唐卫中 余红平 周子寒 |
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| 作者单位： | 广西医科大学附属肿瘤医院；广西医科大学公共卫生学院；区域性高发肿瘤早期防治研究教育部重点实验室 |
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| 基金项目： | 国家自然科学基金项目（81660567）；广西重点研发计划项目（AB18050020；AA18221001）；广西自然科学基金项目（2018GXNSFDA050012）；上海吴孟超医学科技基金项目（JJHXM-2019042）；广西高校中青年教师科研基础能力提升项目（2021KY0099；2021KY0112）；广西卫生健康委员会自筹经费科研课题（Z20200923）；区域性高发肿瘤早期防治研究教育部重点实验室/广西重点实验室开放课题（GKE2018-KF02） |
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| 摘 要： | 目的 分析ABO血型与乙型肝炎病毒(HBV)相关性肝细胞癌(hepatocellular carcinoma,HCC)患者临床病理特征的相关性,并探讨其与HCC肝切除术后预后的关联.方法 回顾性分析2014年1月1日至2017年12月31日于广西医科大学附属肿瘤医院首诊且行肝癌肝切除术并获随访的888例HBV相关性HC...
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| 关 键 词： | 肝细胞癌 ABO血型 总生存率 临床病理特征 |
Association between ABO blood type and prognosis in patients with HBV-related hepatocellular carcinoma after hepatectomy |
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| LIANG Xiumei,JIANG Yanji,ZHOU Zewen,QIU Jialin,GONG Wenfeng,MA Liang,XIANG Bangde,TANG Weizhong,YU Hongping,ZHOU Zihan. Association between ABO blood type and prognosis in patients with HBV-related hepatocellular carcinoma after hepatectomy[J]. Journal of Chinese Medical Abstracts·Oncology, 2021, 13(3): 282-287. DOI: 10.3969/j.issn.1674-5671.2021.03.11 |
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| Authors: | LIANG Xiumei JIANG Yanji ZHOU Zewen QIU Jialin GONG Wenfeng MA Liang XIANG Bangde TANG Weizhong YU Hongping ZHOU Zihan |
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| Abstract: | Objective To analyze the correlation between ABO blood type and clinicopathological characteristics of HBV-associated HCC (HBV-HCC) patients, and to explore the influence of ABO blood type on the prognosis of HCC patients. Methods The clinical data and prognosis of 888 HBV-HCC patients, who were first diagnosed and then followed up at Guangxi Medical University Cancer Hospital and underwent liver cancer resection from January 2014 to December 2017, were retrospectively analyzed. The association between ABO blood type and the overall survival rate of HBV-HCC patients after surgery were analyzed by Cox proportional hazards regression. Results Kaplan-Meier survival analysis showed that the 3-year cumulative overall survival rates of patients with O, A, B and AB blood type were 68%, 59%, 64% and 64%, respectively, and no statistically significant difference was found among different patients (P>0.05). After adjusted for age, gender, smoking history, drinking history, liver cirrhosis, serum AFP level, BCLC stage, and tumor capsular, multivariable Cox regression analyses showed that, compared with patients with type O blood, patients with type A blood had a lower overall survival rate (HR=1.40, 95%CI=1.07-1.83, P=0.015). Further stratified analyses indicated that, among the HCC patients who were male and younger than 55 years old smokers or drinkers or with AFP less than 400 ng/mL and complete tumor capsular (all P<0.05), those with type O blood had higher overall survival rate than those with type A blood. Conclusions Blood type may affect the overall survival rate of HCC patients after resection, and patients with type A blood have a lower overall survival rate. |
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| Keywords: | Hepatocellular carcinoma ABO blood type Overall survival rate Clinicopathological characteristics |
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