Evaluation of Mucosamin Effect on Treating Radiation Induced Oral Mucositis during and after Radiotherapy amongst Patients with Oral Cavity Squamous Cell Carcinoma |
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| Authors: | Hamid Nasrollahi1Saeedeh Khaki1Mansour Ansari2Niloofar Ahmadloo3Nezhat Khanjani1Sayed Hasan Hamedi1Shapoor Omidvari2Ahmad Mosalaei4Mohammad Mohammadianpanah5Behnam Kadkhodaei1 |
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| Affiliation: | 1Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.2Breast Diseases Research Center, Shiraz University of Medical Sciences Shiraz, Iran.3Department of Health Administration, School of Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.4Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.5Colorectal Research Center, Zand, Shiraz, Iran. |
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| Abstract: | Background: Oral mucositis is a serious complication radiation therapy for cancer. This is a major complication during radiation therapy of the head and neck tumors in approximately all patients. Therefore, this study was conducted to evaluate the effect of Mucosamin on treatment of radiation induced oral mucositis during and after radiotherapy amongst patients with oral cavity squamous cell carcinoma. Materials and Methods: In this prospective clinical trial, eligible patients who referred to radiation oncology department of Namazi Hospital, Shiraz, Iran from Jan 2018 till Jan 2019 were evaluated. The cases with confirmed pathologic diagnosis of squamous cell carcinoma of the oral cavity underwent 6,000 cGy radiation therapy and were randomly divided into two groups: 1- Intervention group; Mucosamin spray for 3-4 times a day (n = 40); 2 - Control group; standard medications (3 times a day) (n = 40). Oral mucositis was evaluated weekly based on RTOG scoring scale. Grade of mucositis was recorded during treatment and after radiation therapy. Results: A total of 80 patients were divided in two groups of Mucosamin and control. From week 3 until the end of radiotherapy (week 6) and after radiotherapy (week 8), there was a significant difference in the severity of oral mucositis between the Mucosamin and the control groups (P <0.05). Conclusion: The results of this study showed that Mucosamin spray was able to significantly improved radiation-induced oral mucositis in patients with oral squamous cell carcinoma. |
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| Keywords: | Oral Cavity Squamous Cell Carcinoma radiotherapy Oral Mucositis Mucosamin |
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