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| 胃肠道淋巴瘤Survivin表达与幽门螺杆菌感染的关系及意义 | |
| 引用本文： | 揭旭日, 夏冰, 王小超, 陶丽菊, 陈诗强. 胃肠道淋巴瘤Survivin表达与幽门螺杆菌感染的关系及意义[J]. 中国肿瘤临床, 2008, 35(3): 152-154. |
| 作者姓名： | 揭旭日 夏冰 王小超 陶丽菊 陈诗强 |
| 作者单位： | 1.右江民族医学院附属医院血液内科, 广西壮族自治区百色市 533000;;2.武汉大学中南医院消化内科、过敏与免疫相关疾病研究中心 |
| 基金项目： | 本文课题受广西壮族自治区卫生厅科技计划基金资助（编号：2005231） |
| 摘 要： | 目的: 探讨Survivin基因在胃肠道B细胞淋巴瘤(BCL)中的表达及其与幽门螺杆菌(Helicobacter pylori,HP)感染的关系。 方法: 用免疫组化法检测56例胃肠道BCL和30例正常胃肠组织中Survivin的表达,并用碱性品红染色法检测胃肠道BCL及正常对照组HP感染情况。 结果: 胃BCL中Survivin的表达阳性率46.67%(14/30),肠BCL阳性率42.31%(11/26),两组对比差异无显著性意义(P>0.05);总的胃肠道BCL Survivin表达阳性率44.64%(25/56),在正常胃肠组织均无表达,两组表达阳性率对比差异有显著性(P<0.01);低度恶性胃肠BCLSurvivin表达阳性率20.83%(5/24),高度恶性胃肠BCL阳性率65.63%(21/32),两组阳性率对比差异有显著性(P<0.01)。胃BCLHP检测阳性率46.67%(14/30),肠BCL30.77%(8/26),两组阳性率对比,差异无显著性(P>0.05);56例胃肠道BCLHP阳性率39.29%(22/56),正常对照组13.33%(4/30),两组阳性率对比,差异有显著性意义(P<0.05);MALT(mu-cosa—associated lymphoid tissue,MALT)淋巴瘤HP阳性率66.67%(16/24),非MALT淋巴瘤阳性率18.75%(6/32),两组对比差异有显著性(P<0.01);胃肠BCLSurvivin阳性表达与HP感染有相关性(P<0.05)。 结论: Survivin基因在胃肠道B细胞淋巴瘤中表达上调,而且Survivin表达与HP感染有显著性相关,提示该基因及HP感染对胃肠淋巴瘤发生、发展起重要作用。 |
| 关 键 词： | 胃肠疾病 淋巴瘤 Survivin 幽门螺杆菌 |
| 收稿时间： | 2007-06-18 |
| 修稿时间： | 2007-09-17 |
Association between Survivin Expression and Helicobacter Pylori Infection in Gastrointestinal B Cell Lymphoma |
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| JIE Xu-ri, XIA Bing, WANG Xiao-chao, TAO Li-ju, CHEN Shi-qiang. Association between Survivin Expression and Helicobacter Pylori Infection in Gastrointestinal B Cell Lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(3): 152-154. | |
| Authors: | JIE Xuri XIA Bing WANG Xiaochao TAO Liju CHEN Shiqiang |
| Affiliation: | 1.Department of Hematology, Affiliated Hospital of Youjiang National Medical College, Baise 533000, China;;2.Research Center of Gastrointestinal, Allergic and Immunological Disease, Zhongnan Hospital of Wuhan University, Wuhan430071, China |
| Abstract: | Objective: To investigate the association between Survivin expression and helicobacter pylori (HP) infec-tion in gastrointestinal B cell Lymphoma (BCL). Methods: Using immunohistochemistry, we detected the expression ofSurvivin genes in tissues from 56 cases of gastrointestinal BCL (30 cases of gastric BCL and 26 cases of intestinal BCL)and 30 normal gastrointestinal mucosal tissue samples. HP was detected by histological fuchsine staining. Results: Sur-vivin expression was found in 14 of the 30 cases of gastric BCL (46.67%) and in 11 of the 26 cases of intestine BCL(30.77%). There was not significant difference between the two groups (P>0.05). The total expression rate of Survivin was44.64%(25/56) in gastrointestinal BCL group and 0% in the control group (P<0.01). The expression rate of Survivin was20.83%(5/24) in low malignant gastrointestinal BCL and 65.63%(21/32) in high malignant gastrointestinal BCL, with a sig-nificant difference (P<0.01). The infective rate of HP was 46.67%(14/30) in gastric BCL and 30.77%(8/26) in intestinalBCL, with no significant difference(P>0.05). The infective rate of HP was 39.29%(22/56) in the gastrointestinal BCL groupand 13.33%(4/30) in the normal group, with a statistical significance (P<0.05). The HP positive rate was 66.67%(16/24) inmucosa-associated lymphoid tissue(MALT) lymphoma and 18.75%(6/32) in non-MALT lymphoma(P<0.01). The expressionof Survivin in gastrointestinal BCL was related to HP infection. Conclusion: The expression of Survivin involves in the de-velopment of gastrointestinal BCL and is related to HP infection. |
| Keywords: | Gastrointestinal disease Lymphoma Survivin Helicobacter pylori |
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