| 单纯性肥胖症患者外周血ghrelin、obestatin的水平变化及其临床意义 |
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| 引用本文： | 徐海蓉,郑兴,郭志福. 单纯性肥胖症患者外周血ghrelin、obestatin的水平变化及其临床意义[J]. 心脏杂志, 2009, 21(1): 95-98 |
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| 作者姓名： | 徐海蓉 郑兴 郭志福 |
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| 作者单位： | 1.第二军医大学长海医院心内科，上海 200433；2．武警新疆总队医院心内科，新疆 乌鲁木齐 830000 |
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| 摘 要： | 目的 探讨单纯性肥胖症患者餐前、餐后外周血肥胖抑制素（obestatin）水平的变化及其与ghrelin（一种脑肠肽激素）间的关系。方法 采用放射免疫法（RIA）检测16例单纯性肥胖症患者和14例正常对照者餐前1 h及其中各10例餐后2 h外周血ghrelin、obestatin水平；同时采用酶联免疫分析法（ELISA）检测餐前胰岛素水平并监测体质量指数（BMI）、腰臀比、血糖、血脂、白细胞及超敏C反应蛋白。结果 单纯性肥胖症患者餐前外周血ghrelin和obestatin水平均低于正常对照组（均P<0.01），但ghrelin/obestatin比值却明显高于正常对照组（P<0.01）。单纯性肥胖症组和正常对照组餐后ghrelin/obestatin比值均明显低于其餐前（分别P<0.05，P<0.01），但两组间差异无统计学意义。相关分析显示餐前ghrelin/obestatin比值与BMI（r=0.54，P<0.01）、腰围（r=0.39，P<0.05）、总胆固醇（r=0.40，P<0.05）和低密度脂蛋白胆固醇（r=0.41，P<0.05）呈正相关；与其它指标间相关性无统计学意义。结论 餐前外周血ghrelin、obestatin间比例失衡可能是单纯性肥胖症的发病机制之一。
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| 关 键 词： | 脑肠肽激素 肥胖抑制素 肥胖症 |
Study on circulating levels of ghrelin and obestatin in human simple obesity |
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| XU Hai-rong,ZHENG Xing,CUO Zhi-fu. Study on circulating levels of ghrelin and obestatin in human simple obesity[J]. Chinese Heart Journal, 2009, 21(1): 95-98 |
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| Authors: | XU Hai-rong ZHENG Xing CUO Zhi-fu |
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| Abstract: | AIM To investigate preprandial and postprandial changes of circulating ghrelin and obestatin levels in simple obesities. METHODS Plasma ghrelin and obestatin concentrations 1 hour before meal were measured by radioimmunoassay in 16 simple obese adolescents and 14 normal controls. Body mass index, waist-hip ratio, plasma glucose, plasma insulin, blood lipids, white blood cells count and high sensitive C-reactive protein were measured. Plasma ghrelin and obestatin concentrations 2 hours after meal were measured in 10 of the simple obese adolescents and 10 of the controls. RESULTS Although both prepramdial plasma ghrelin (P<0.01) and obestatin (P<0.05) concentrations decreased in simple obesities as compared with those in normal controls (both P<0.01), their ratios of ghrelin to obestatin were increased (P<0.01) even after adjustment for gender and age. The ratios of postprandial ghrelin to postprandial obestatin decreased both in simple obesities (P<0.05) and normal controls (P<0.01) compared with their preprandial ratios, but the postprandial ratios were similar between simple obesities and normal controls. There were significant positive correlations respectively between prepramdial ghrelin/obestatin and BMI (r=0.54, P<0.01), waist circumference (r=0.39, P<0.05), total cholesterol (r=0.40, P<0.05), low-density lipoprotein cholesterol (r=0.41, P<0.05). CONCLUSION The imbalance of prepramdial circulating ghrelin and obestatin may play a role in the pathogenesis of human obesity. |
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