| 6种云南天然药物对口腔优势菌的抗菌活性测定 |
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| 引用本文： | 李艳红,刘娟,杨丽川,张灿华,李罡. 6种云南天然药物对口腔优势菌的抗菌活性测定[J]. 华西口腔医学杂志, 2010, 28(2): 199-202. DOI: 10.3969/j.issn.1000-1182.2010.02.021 |
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| 作者姓名： | 李艳红 刘娟 杨丽川 张灿华 李罡 |
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| 作者单位： | 昆明医学院附属口腔医院,口腔预防儿童牙科;昆明医学院药学院,医药化学系;昆明医学院附属口腔医院,口腔修复科,云南,昆明,650031 |
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| 基金项目： | 云南省科技厅面上基金资助项目 |
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| 摘 要： | 目的测定6种云南天然药物对口腔临床常见优势菌的体外抗菌活性,从而初步确定其在口腔临床的药用价值。方法采用美国国立实验室标准化委员会推荐的厌氧菌药物敏感试验---琼脂稀释法,测定6种云南天然药物对21株口腔临床常见优势菌模式株、临床分离株的体外抗菌活性,用最小抑菌浓度（MIC）表示。结果6种药物对21株实验细菌均有抗菌作用：对10株致龋菌的MIC值范围：苏木为5~10 mg·mL-1;其他5种药物（丽江山慈菇、滇龙胆、诃子、龙血竭、杜仲）均大于20 mg·mL-1。对11株牙髓根尖周炎和牙周病的常见优势菌的MIC值范围：苏木均小于等于0.062 5 mg·mL-1;诃子为10~20 mg·mL-1;其他4种实验药物均大于20 mg·mL-1。结论6种药物在口腔细菌性疾病的临床治疗中具有潜在的药用价值。
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| 关 键 词： | 口腔优势菌 抗菌活性 天然药物 |
| 收稿时间： | 2010-04-25 |
| 修稿时间： | 2010-04-25 |
Antibacterial activity determination of six kinds of natural herbs in Yunnan on normal oral predominant bacteria in vitro |
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| LI Yan-hong,LIU Juan,YANG Li-chuan,ZHANG Can-hua,LI Gang. Antibacterial activity determination of six kinds of natural herbs in Yunnan on normal oral predominant bacteria in vitro[J]. West China journal of stomatology, 2010, 28(2): 199-202. DOI: 10.3969/j.issn.1000-1182.2010.02.021 |
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| Authors: | LI Yan-hong LIU Juan YANG Li-chuan ZHANG Can-hua LI Gang |
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| Affiliation: | 1. Dept. of Preventive and Pediatric Dentistry, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming 650031, China; 2. Dept. of Medical and Pharmaceutical Chemistry, School of Pharmocology, Kunming Medical University, Kunming, 650031, China; 3. Dept. of Prosthodontics, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming 650031, China |
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| Abstract: | Objective To determine the antibacterial activity of six kinds of natural herbs in Yunnan on normal oral predominant bacteria in vitro. Methods Agar dilution method, the antimicrobial susceptibility testing of anaerobes which was recommended by National Committee for Clinical Laboratory Standard (NCCLs), was used to determine the antimicrobial susceptibility of herbs to 21 kinds of oral model strains and clinical isolates. The results were expressed by minimum inhibitory concentration (MIC). Results All six kinds of herbs were effective to the oral predominant bacteria. For the ten kinds of cariogenic bacteria, the MIC of caesalpinia sappan lignum was between 5-10 mg·mL~(-1), and the MIC of other herbs was above 20 mg·mL~(-1). For the eleven kinds of predominant bacteria which normally involved in pulp periapical disease and periodontitis, the MIC of caesalpinia sappan lignum was below 0.062 5 mg·mL~(-1), and the MIC of the terminalia chebula retz was between 10-20 mg·mL~(-1), and the others were above 20 mg·mL~(-1). Conclusion The six kinds of herbs in Yunnan could be used in treatment or prevention of oral bacterial diseases. |
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| Keywords: | oral predominant bacteria antibacterial activity natural herb |
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