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Efficacy and Tolerability of Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid‐Induced Constipation: A Responder Analysis of 2 Randomized,Placebo‐Controlled Trials
Authors:Srinivas R. Nalamachu MD  Joseph Pergolizzi MD  Robert Taylor PhD Jr  Neal E. Slatkin MD  Andrew C. Barrett PhD  Jing Yu PhD  Enoch Bortey PhD  Craig Paterson MD  William P. Forbes PharmD
Affiliation:1. International Clinical Research Institute, Overland Park, Kansas, U.S.A;2. Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A;3. Temple University School of Medicine, Philadelphia, Pennsylvania, U.S.A;4. Association of Chronic Pain Patients, Naples, Florida, U.S.A;5. NEMA Research Inc., Naples, Florida, U.S.A;6. Palliative Care Center Silicon Valley and Hospice of the Valley, San Jose, California, U.S.A;7. Salix Pharmaceuticals Inc., Raleigh, North Carolina, U.S.A
Abstract:
Keywords:opioid‐induced constipation  methylnaltrexone  μ  ‐opioid receptor  opioids
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